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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
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Médecine
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Journal JoVE Médecine
Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

DOI:
10.3791/57261-v

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09:37 min

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August 01, 2018

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, , , , ,
1Div. of Gastroenterology and Hepatology, Dept. of Internal Medicine III,Medical University of Vienna, Vienna, Austria, 2Vienna Hepatic Hemodynamic Laboratory,Medical University of Vienna, Vienna, Austria, 3Center of Biomedical Research,Medical University of Vienna, Vienna, Austria

Chapitres

  • 00:04Titre
  • 00:46Preparing the Rat for Surgery
  • 01:53Measurement of Heart Rate and Mean Arterial Pressure
  • 04:01Measurement of Superior Mesenteric Artery Blood Flow (SMABF)
  • 05:53Measurement of Portal Vein Blood Flow
  • 06:39Measurement of Portal Pressure
  • 07:32Results: Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
  • 08:52Conclusion

Summary

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Here we describe a detailed protocol for invasive measurements of hemodynamic parameters including portal pressure, splanchnic blood flow, and systemic hemodynamics in order to characterize the portal hypertensive syndrome in rats.

Tags

Invasive Hemodynamic CharacterizationPortal-hypertensive SyndromeCirrhotic RatsPortal Pressure MeasurementHemodynamic ParametersLiver FibrosisPortal HypertensionAnesthesiaIntubationFemoral Artery DissectionLigatureMicro Clamp

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