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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

DOI:
10.3791/57572-v

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11:45 min

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August 22, 2018

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,
1Department of Chemistry,North Eastern Regional Institute of Science and Technology, 2Department of Chemistry,Hankuk University of Foreign Studies

Chapitres

  • 00:04Titre
  • 00:35Synthesis of (6R)-1-[(R)-1-Phenylethyl)-1-Azoniabicyclo[4.1.0]Heptane Tosylate
  • 02:49General Procedure for the Expansion of 1-Azoniabicyclo[4.1.0]Heptane Tosylate
  • 03:53Synthesis of (S)-1-[(R)-1-Phenylethyl]azepan-3-ol
  • 05:14Synthesis of [(2R,3R,4R)-3,4-Bis(Benzyloxy)-1-(S)-1-Phenylethyl)Piperidin-2-Yl]Methyl Acetate
  • 08:03Results: Synthesis and Characterization of Bicyclic Aziridinium Ions and its Ring Expansion to Azaheterocycles
  • 09:53Conclusion

Summary

Traduction automatique

Traduction automatique

Bicyclic aziridinium ions such as 1-azoniabicyclo[4.1.0]heptane tosylate were generated from 2-[4-tolenesulfonyloxybutyl]aziridine, which was utilized for the preparation of substituted piperidines and azepanes via regio- and stereospecific ring-expansion with various nucleophiles. This highly efficient protocol allowed us to prepare diverse azaheterocycles including natural products such as fagomine, febrifugine analogue and balanol.

Tags

Bicyclic Aziridinium IonsAzaheterocyclesBipyridineAzepineTosylateNucleophileRing-openingAzoniabicycloDichloromethaneAcetonitrile

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