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Generasjon og behovsbetinget initiering av akutt Ictal aktivitet i gnagere og menneskelig vev
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1Division of Fundamental Neurobiology,Krembil Research Institute, 2Institute of Medical Science, Faculty of Medicine,University of Toronto, 3Institute of Biomaterials and Biomedical Engineering,University of Toronto, 4Division of Neurosurgery, Department of Surgery,University of Toronto, 5Division of Neurology, Department of Medicine,University of Toronto, 6Department of Physiology,University of Toronto
Chapters
- 00:04Title
- 00:46Preparation of Cortical Slices from the Somatosensory-motor Cortex
- 02:40Electrophysiological Recordings of the Superficial Cortical Layer and Seizure Induction
- 04:43Results: Acute In Vitro 4-AP Cortical Seizure Model and Ictal Events Generated by Optogenetics
- 06:19Conclusion
Akutt anfall modeller er viktig for å studere mekanismer underliggende epileptiform hendelser. I tillegg gir muligheten til å generere epileptiform hendelser på forespørsel en svært effektiv metode for å studere den nøyaktige sekvensen av hendelser underliggende deres innvielse. Her beskriver vi akutt 4-aminopyridine kortikale anfall modeller etablert i musen og menneskelig vev.
