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Immunology and Infection

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JoVE Journal Immunology and Infection
Evaluering af Zika Virus-specifikke T-celle respons i Immunoprivileged organer af inficerede Ifnar1- / - mus
 
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Evaluering af Zika Virus-specifikke T-celle respons i Immunoprivileged organer af inficerede Ifnar1- / - mus

Article DOI: 10.3791/58110-v • 10:01 min • October 17th, 2018
October 17th, 2018 •
*1,2, *2, *3, 1,2, 4, 2, 5, 6, 3, 1,2,4,6, 1,2
1School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 2NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 3State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, 4Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, 5Laboratory Animal Center, Chinese Center for Disease Control and Prevention, 6CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
* These authors contributed equally

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En protokol til at evaluere antigen-specifikke T-celle respons i immunoprivileged organerne i Ifnar1- / - murine model for Zika virusinfektion (ZIKV) er beskrevet. Denne metode er afgørende for at undersøge de cellulære mekanismer i beskyttelse og immunpatogenese af ZIKV vacciner og er også værdifulde for deres effekt evaluering.

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Immunologi og infektion spørgsmål 140 Zika virus antigen-specifikke T-celle vaccination immunoprivileged organer tetramer
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