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Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles
Journal JoVE
Recherche en cancérologie
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Journal JoVE Recherche en cancérologie
Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles
DOI:

05:55 min

September 18, 2018

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Chapitres

  • 00:04Titre
  • 00:35Synthesis of DNPs
  • 01:34Conjugation of Peptides to DNPs
  • 02:54Fluorescence Microscopy Assessment of pICSA-Targeted Nanoparticle Uptake in Choriocarcinoma (JEG3) Cells
  • 04:18Results: Characterization and Cellular Uptake of plCSA-DNPs
  • 05:12Conclusion

Summary

Traduction automatique

Here, we present a protocol for the synthesis of placental chondroitin sulfate A binding peptide (plCSA-BP)-conjugated lipid-polymer nanoparticles via single-step sonication and bioconjugate techniques. These particles constitute a novel tool for the targeted delivery of therapeutics to most human tumors and placental trophoblasts to treat cancers and placental disorders.

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