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A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
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Biologie du développement
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Journal JoVE Biologie du développement
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

DOI:
10.3791/58379-v

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08:20 min

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October 02, 2018

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, , , , , ,
1Department of Pediatrics,Johns Hopkins University School of Medicine, 2Department of Health,Beijing Military General Hospital, 3Southern Medical University, 4Department of Molecular and Cellular Physiology,Johns Hopkins University School of Medicine, 5Department of Gynecology and Obstetrics,Johns Hopkins University School of Medicine

Chapitres

  • 00:04Titre
  • 00:47Dihydrotestosterone (DHT) Pellet Preparation
  • 02:04DHT Insertion and Replacement
  • 04:56Reproductive Profile Assessment of Female Offspring from Chronically DHT-inserted Dams
  • 06:27Results: Representative Mouse PCOS Model Analyses
  • 07:28Conclusion

Summary

Traduction automatique

Traduction automatique

We describe the development of a lean PCOS-like mouse model with dihydrotestosterone pellet to study the pathophysiology of PCOS and the offspring from these PCOS-like dams.

Tags

Polycystic Ovary SyndromePCOSHyperandrogenismDihydrotestosteroneDHTMouse ModelSilicone TubingPellet ImplantationSurgical ProcedureAndrogen Exposure

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