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猪自体移植肝细胞外细胞外细胞基因治疗

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Médecine

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Journal JoVE Médecine

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

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猪自体移植肝细胞外细胞外细胞基因治疗

DOI:

10.3791/58399-v

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09:54 min

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November 04, 2018

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Robert A. Kaiser², Shennen A. Mao, Jaime Glorioso, Bruce Amiot, Clara T. Nicolas, Kari L. Allen, Zeji Du, Caitlin J VanLith, Raymond D. Hickey, Scott L. Nyberg, Joseph B. Lillegard^2,4

¹Department of Surgery,Mayo Clinic, ²Midwest Fetal Care Center,Children’s Hospitals and Clinics of Minnesota, ³Department of Surgery,Johns Hopkins, ⁴Pediatric Surgical Associates

Chapitres

00:04Titre
01:22Laparoscopic Partial Hepatectomy
03:28Hepatocyte Isolation and Transplantation
07:24Results: Representative Lentiviral Vector-mediated Hepatocyte Liver Function Rescue
09:09Conclusion

Summary

Traduction automatique

本方案旨在描述猪肝细胞分离和体外基因传递, 通过自体细胞移植治疗代谢疾病模型。虽然这种特殊的模式具有独特的优势, 有利于成功的治疗, 但应用是解决其他疾病和适应症的相关基础。

Tags

Lentiviral Vector Gene Therapy Hepatocytes Ex Vivo Autologous Transplantation Inborn Errors Of Metabolism Liver Disease Hereditary Tyrosinemia Type 1 Surgical Procedure Laparoscopic Technique Liver Resection

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