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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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Sciences du comportement
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Journal JoVE Sciences du comportement
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

DOI:
10.3791/58875-v

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04:38 min

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May 22, 2019

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, , , , , , , , ,
1Department of Anesthesiology and Critical Care, Soroka University Medical Center, Faculty of Health Sciences,Ben-Gurion University of the Negev, 2Department of Neurosurgery, Soroka University Medical Center, Faculty of Health Sciences,Ben-Gurion University of the Negev, 3Department of Biophysics and Biochemistry, Faculty of Biology, Ecology, and Medicine,Oles Honchar Dnipro National University

Chapitres

  • 00:04Titre
  • 00:33Middle Cerebral Artery Occlusion (MCAO)
  • 01:09Neurological Severity Score and Infarct Volume Measurement
  • 01:56Sucrose Preference Test
  • 02:44Porsolt s Forced-swim Test
  • 03:26Results: Proof of Occlusion
  • 04:14Conclusion

Summary

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Here we present a protocol to induce post-stroke depression in rats by occluding the middle cerebral artery via the internal carotid artery. We use the Porsolt forced swim test and the sucrose preference test to confirm and evaluate induced depressive moods.

Tags

Middle Cerebral Artery OcclusionPost-stroke DepressionRat ModelNeurological Severity ScoreInfarct VolumeSucrose Preference TestForced Swim Test

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