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Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research
 

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Article DOI: 10.3791/59458-v • 09:36 min • April 26th, 2019
April 26th, 2019 •
1, 2,3, 2,3, 2,4, 2,4, 1, 2,4
1Christine M. Kleinert Institute for Hand and Microsurgery, 2Cardiovascular Innovation Institute, University of Louisville, 3Kentucky Spinal Cord Injury Research Center, University of Louisville, 4Department of Physiology, University of Louisville

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résumé
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Vascularized composite allograft offers life-altering benefits to transplant recipients, but the biological causes of graft rejection and vasculopathy remain poorly understood. The rodent surgical model presented here offers a reproducible, clinically relevant model of transplantation, allowing researchers to evaluate rejection events and potential therapeutic strategies to prevent their occurrence.

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Keywords: Vascularized Composite Allotransplantation Hindlimb Osteomyocutaneous Flap Rat Model Vasculopathy Graft Rejection Macrovascular Surgical Techniques Ischemic Damage Skin Muscle Bone Orthotopic Models Hand Transplant Donor Vessels Recipient Surgical Site Inguinal Pocket
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