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JoVE Journal Neuroscience
Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
 

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Article DOI: 10.3791/59675-v • 08:22 min • July 18th, 2019
July 18th, 2019 •
1, 1, 1, 1
1Institute of Laboratory Animal Science, University of Zurich

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Convection-enhanced delivery (CED) is a method enabling effective delivery of therapeutics into the brain by direct perfusion of large tissue volumes. The procedure requires the use of catheters and an optimized injection procedure. This protocol describes a methodology for CED of an antibody into a mouse brain.

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Keywords: Convection-enhanced Delivery Antibody Delivery Brain Murine Step Catheter Blood-brain Barrier Fused Silica Capillary Cyanoacrylate Adhesive Stereotactic Robot Agarose Gel Trypan Blue
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