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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
Journal JoVE
Médecine
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Journal JoVE Médecine
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

DOI:
10.3791/59701-v

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10:21 min

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August 08, 2019

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, , , , , , , ,
1Institute of Anatomy,Rostock University Medical Center, 2Department of Nuclear Medicine,Rostock University Medical Center, 3Core Facility Multimodal Small Animal Imaging,Rostock University Medical Center, 4Rudolf-Zenker-Institute for Experimental Surgery,Rostock University Medical Center

Chapitres

  • 00:04Titre
  • 01:05Animal Catheterization
  • 03:31Image Acquisition and Reconstruction
  • 06:41Manual and Online Blood Sampling
  • 08:31Results: Representative Continuous and Manual Blood Sampling Results
  • 09:47Conclusion

Summary

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Here a protocol for continuous blood sampling during PET/CT imaging of rats to measure the arterial input function (AIF) is described. The catheterization, the calibration and setup of the system and the data analysis of the blood radioactivity are demonstrated. The generated data provide input parameters for subsequent bio-kinetic modeling.

Tags

Continuous Blood SamplingSmall AnimalPET/CTArterial Input FunctionExtracorporeal Arteriovenous ShuntBiokinetic ModelingCross-calibrationFemoral VeinFemoral ArteryCatheter PlacementMicrosurgery

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