Un abonnement à JoVE est nécessaire pour voir ce contenu. Connectez-vous ou commencez votre essai gratuit.
Chapitres
- 00:04Titre
- 00:42Preparation of Reaction Mixture
- 01:42Heating the Reaction in The Microwave Reactor
- 02:35Isolation of The Product by Vacuum Filtration
- 03:52Results: NMR Spectrum
- 04:25Conclusion
1-Aryl-1H-pyrazole-5-amines are prepared from aryl hydrazines combined with either 3-aminocrotononitrile or an α-cyanoketone in a 1 M HCl solution using a microwave reactor. Most reactions are done in 10-15 minutes and pure product can be obtained via vacuum filtration with typical isolated yields of 70-90%.
