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Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro
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Neurosciences
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Journal JoVE Neurosciences
Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro

Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro

DOI:
10.3791/60044-v

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00:06 min

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August 28, 2019

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, , ,
1Discipline of Physiology, Sydney Medical School,University of Sydney, 2Bosch Institute, Sydney Medical School,University of Sydney, 3The MARCS Institute,Western Sydney University, 4Department of Pharmacology, Physiology & Neuroscience,Rutgers Biomedical and Health Sciences

Chapitres

  • 00:04Titre
  • 00:45Brainstem Preparation
  • 02:27Whole-Cell Patch Clamp Electrophysiology
  • 04:10Sinusoidal and Stochastic Noise Application
  • 04:59Results: Representative Effects of Sinusoidal and Stochastic Noise on MVN Neuronal Firing Rates and Gains
  • 05:57Conclusion

Summary

Traduction automatique

Traduction automatique

Galvanic vestibular stimulation in humans exhibits improvements in vestibular function. However, it is unknown how these effects occur. Here, we describe how to apply sinusoidal and stochastic electrical noise and evaluate appropriate stimulus amplitudes in individual medial vestibular nucleus neurons in the C57BL/6 mouse.

Tags

Keywords: Stochastic NoiseMedial Vestibular NucleusNeuron SensitivityIn VitroElectrophysiologyPatch ClampBrain SliceMouseBrainstemEquilibriumACSFNeuronal ResponseStimulus Parameters

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