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Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
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Journal JoVE Médecine
Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

DOI:
10.3791/60105-v

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00:08 min

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August 24, 2019

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, , , , , , , ,
1Department of Surgery,University of Virginia School of Medicine, 2Department of Surgery,Ochsner Medical Center, 3Department of Surgery,University of Florida, 4The Robert M. Berne Cardiovascular Research Center,University of Virginia School of Medicine

Chapitres

  • 00:04Titre
  • 00:33Mouse Position Preparation
  • 01:09Thorax Entry
  • 02:24Aortic Exposure
  • 03:04Elastase Exposure
  • 03:48Chest Closure and Recovery
  • 04:28Thoracic Aortic Aneurysm (TAA) Harvest
  • 06:58Results: Representative Effects of TAA Formation
  • 07:54Conclusion

Summary

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We describe a surgical protocol to consistently induce robust descending thoracic aortic aneurysms in mice. The procedure involves left thoracotomy, thoracic aorta exposure, and placement of a sponge soaked in porcine pancreatic elastase on the aortic wall.

Tags

Murine Surgical ModelTopical ElastaseDescending Thoracic Aortic AneurysmC57 Black Six MouseThoracotomyAortic DissectionPorcine Pancreatic Elastase

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