Journal
/
Chimie
/
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Journal JoVE
Chimie
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Chimie
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

DOI:
10.3791/60184-v

•

08:59 min

•

December 03, 2020

•

, , , , , , , , ,
1Brazilian Biosciences National Laboratory (LNBio),Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS),Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology,University of Campinas

Summary

Traduction automatique

Traduction automatique

We exposed a microphysiological system (MPS) with intestine and liver organoids to acetaminophen (APAP). This article describes the methods for organoid production and APAP pharmacokinetic and toxicological property assessments in the MPS. It also describes the tissue functionality analyses necessary to validate the results.

Tags

Keywords: Microphysiological SystemPharmacokinetic AssessmentToxicological AssessmentIntestineLiverDrug TestingIn VitroOrgan-on-a-chipAcetaminophenHPLC AnalysisCell Viability

Article

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

check_url/fr/60184?article_type=v

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
check_url/fr/60184?article_type=v

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
check_url/fr/60184?article_type=v

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
check_url/fr/60184?article_type=v

PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis
check_url/fr/60184?article_type=v

An Aptamer-based Sensor for Unchelated Gadolinium(III)
check_url/fr/60184?article_type=v

Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry
check_url/fr/60184?article_type=v

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
check_url/fr/60184?article_type=v

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
check_url/fr/60184?article_type=v

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
check_url/fr/60184?article_type=v

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

Read Article