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Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
Journal JoVE
Bio-ingénierie
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Journal JoVE Bio-ingénierie
Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
DOI:

10:24 min

September 19, 2019

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Chapitres

  • 00:04Titre
  • 01:09Fabrication of Metal Plate Holder and Cell Line Seeding
  • 03:05Setting up Thermal Control Unit and Gas Supply System
  • 03:50Installation of Microfluidic Device
  • 08:12Results: Growth Curves and Cell Motility Assay
  • 09:33Conclusion

Summary

Traduction automatique

We present a microfluidic cancer-on-chip model, the "Evolution Accelerator" technology, which provides a controllable platform for long-term real-time quantitative studies of cancer dynamics within well-defined environmental conditions at the single-cell level. This technology is expected to work as an in vitro model for fundamental research or pre-clinical drug development.

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