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重建显微外科缺血再灌注损伤研究的临床前大鼠模型

Journal JoVE
Médecine

This content is Free Access.

Journal JoVE Médecine

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

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重建显微外科缺血再灌注损伤研究的临床前大鼠模型

DOI:

10.3791/60292-v

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08:05 min

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November 08, 2019

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Alberto Ballestín, Javier G. Casado, Elena Abellán, Francisco Javier Vela, José Luis Campos, Guadalupe Martínez-Chacón, Jorge Bote, Rebeca Blázquez, Francisco Miguel Sánchez-Margallo^2,3

¹Department of Microsurgery,Jesús Usón Minimally Invasive Surgery Centre, ²Stem Cell Therapy Unit,Jesús Usón Minimally Invasive Surgery Centre, ³Animal Modelling Unit,Jesús Usón Minimally Invasive Surgery Centre

Chapitres

00:04Titre
01:26Free Skin Flap Model Surgery
03:00Intraoperative Assessment
05:18Postoperative Assessment and Tissue Sampling
06:00Results: Ischemia-Reperfusion Injury in Reconstructive Microsurgery
07:03Conclusion

Summary

Traduction automatique

本文描述了一个临床前动物模型，用于研究重建显微外科中缺血再灌注损伤的病理生理学。这种基于大鼠表面的胆皮外胃血管的自由皮瓣模型也可以允许评估不同的疗法和化合物，以抵消缺血-再灌注损伤相关的损伤。

Tags

Keywords: Pre-clinical Rat Model Ischemia-reperfusion Injury Reconstructive Microsurgery Flap Failure Superficial Caudal Epigastric Vessels Ischemia Reperfusion Microsurgical Reconstruction Innate Immunity Vascular Pedicle Microcirculatory Perfusion Microvascular Anastomosis Transit-time Ultrasound Flowmetry

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