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肽受体放射性核素治疗（PRRT）全身多体型测定方案：2D平面图像和混合2D+3D SPECT/CT图像方法
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Médecine
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Journal JoVE Médecine
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
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肽受体放射性核素治疗（PRRT）全身多体型测定方案：2D平面图像和混合2D+3D SPECT/CT图像方法

DOI:
10.3791/60477-v

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09:49 min

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April 24, 2020

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, , , , , , , , , , , , , , ,
1Medical Physics Unit,Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 2Oncology Pharmacy,Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 3Nuclear Medicine Unit,Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 4Radiation Research Unit,Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy, 5Medical Physics Unit,Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy

Chapitres

  • 00:04Introduction
  • 01:24Pre-Infusion Imaging: Transmission and Blank Image Acquisition
  • 02:35Post-Infusion Image Acquisition: Planar Image
  • 03:21Post-Infusion Image Acquisition: 3D SPECT/CT
  • 03:51Image Analysis
  • 04:58Blood Sample Measurements and Dosimetry Evaluation
  • 05:50Hybrid 2D+3D SCPET/CT Image Analysis
  • 06:21Adult Phantom Creation and Red Marrow Evaluation
  • 07:50Results: Representative Comparison of 2D, Hybrid 2D+3D, and 3D SPECT/CT Methods for Transient Intestine Uptake Overlap on Kidneys
  • 08:35Conclusion

Summary

Traduction automatique

Traduction automatique

该方法估计了不同结构对肽受体-放射性核素治疗（PRRT）的吸收剂量，从而避免了器官在2D投影上的重叠。串行全身平面图像允许估计整个身体的平均吸收剂量，而混合方法，结合平面图像和3D-SPECT/CT图像，克服了结构重叠的限制。

Tags

Peptide-Receptor Radionuclide Therapy (PRRT)Dosimetry2D Planar ImagingSPECT/CTHybrid ImagingWhole-Body DosimetryAbsorbed Dose EstimationRadioligand InjectionAttenuation CorrectionImage AcquisitionEffective Half-LifeMean Absorbed Dose

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