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大鼠关节内注射单碘乙酸酯诱导的骨关节炎疼痛模型

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Médecine

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Journal JoVE Médecine

Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats

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大鼠关节内注射单碘乙酸酯诱导的骨关节炎疼痛模型

DOI:

10.3791/60649-v

•

08:09 min

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May 20, 2020

•

Jiaan Xu², Li Yan², Bo Yan², Li Zhou, Peijian Tong, Letian Shan

¹The First Affiliated Hospital,Zhejiang Chinese Medical University, ²College of Pharmaceutical Science,Zhejiang Chinese Medical University

Chapitres

00:04Introduction
00:47Intra‐Articular Mono‐Iodoacetate (MIA) Injection
01:48Mechanical Withdrawal Threshold (MWT)
03:00Thermal Withdrawal Latency (TWL)
04:17Gait Pattern Analyses
05:39Results: Representative MIA Development and Characterization
07:16Conclusion

Summary

Traduction automatique

本研究描述了大鼠关节内注射单碘乙酸酯的方法，并讨论了由此产生的疼痛相关行为和组织病理学变化，为今后的应用提供参考。

Tags

Keywords: Osteoarthritis Pain Model Mono-iodoacetate Intra-articular Injection Rats Paw Withdrawal Threshold Thermal Withdrawal Latency Behavioral Testing

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