Journal
/
Médecine
/
Intratracheal Administration of Dry Powder Formulation in Mice
Journal JoVE
Médecine
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Médecine
Intratracheal Administration of Dry Powder Formulation in Mice

Intratracheal Administration of Dry Powder Formulation in Mice

DOI:
10.3791/61469-v

•

07:55 min

•

July 25, 2020

•

, , ,
1Department of Pharmacology and Pharmacy, LKS Faculty of Medicine,The University of Hong Kong, 2Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health,The University of Sydney

Chapitres

  • 00:04Introduction
  • 01:22Fabrication of Dry Powder Insufflator and Loading of Dry Powder
  • 02:36Intubation
  • 04:17Powder Administration
  • 05:25Results: Optimization of Intratracheal Administration of mRNA Formulation
  • 07:23Conclusion

Summary

Traduction automatique

Traduction automatique

Dry powder formulations for inhalation have great potential in treating respiratory diseases. Before entering human studies, it is necessary to evaluate the efficacy of the dry powder formulation in preclinical studies. A simple and noninvasive method of the administration of dry powder in mice through the intratracheal route is presented.

Tags

Keywords: Intratracheal AdministrationDry Powder FormulationMiceInsufflatorPulmonary AbsorptionBioavailabilityTherapeutic EffectsPre-clinical Animal ModelsIntubationStatic ChargesGel Loading Pipette TipWeighing PaperSyringeAnesthesiaBALB/c MouseOptical FiberGuiding Cannula

Article

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

check_url/fr/61469?article_type=v

A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
check_url/fr/61469?article_type=v

Intranasal Administration of CNS Therapeutics to Awake Mice
check_url/fr/61469?article_type=v

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
check_url/fr/61469?article_type=v

Intubation-mediated Intratracheal (IMIT) Instillation: A Noninvasive, Lung-specific Delivery System
check_url/fr/61469?article_type=v

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
check_url/fr/61469?article_type=v

A Pleural Effusion Model in Rats by Intratracheal Instillation of Polyacrylate/Nanosilica
check_url/fr/61469?article_type=v

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation
check_url/fr/61469?article_type=v

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
check_url/fr/61469?article_type=v

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease
check_url/fr/61469?article_type=v

Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models (Video) | JoVE

Read Article