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Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
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Médecine
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Journal JoVE Médecine
Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

DOI:
10.3791/61546-v

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07:50 min

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September 03, 2020

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, , , ,
1Department of Cardiovascular Medicine,Mayo Clinic, 2Department of Radiology and Molecular Imaging Program at Stanford (MIPS),Stanford University School of Medicine

Chapitres

  • 00:04Introduction
  • 00:54Preparation and Intubation
  • 02:10Ischemia Reperfusion Injury
  • 04:15Mouse Mesenchymal Stem Cell Delivery
  • 06:07Results: Heart Function after Ischemic Injury
  • 07:05Conclusion

Summary

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Stems cells are continuously investigated as potential treatments for individuals with myocardial damage, however, their decreased viability and retention within injured tissue can impact their long-term efficacy. In this manuscript we describe an alternative method for stem cell delivery in a murine model of ischemia reperfusion injury.

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AI-assisted WritingStem Cell TherapyIschemia-reperfusion InjuryDelayed Cell DeliverySurgical ProcedureMurine Model

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