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Immunology and Infection

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JoVE Journal Immunology and Infection
Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
 

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Article DOI: 10.3791/61551-v • 09:35 min • April 20th, 2021
April 20th, 2021 •
1, 2, 1, 1
1Department of Biology, The City College of New York and The Graduate Center of The City University of New York, 2Department of Microbiology, Icahn School of Medicine at Mount Sinai

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résumé
Automatic Translation

Presented here is an assay to quantify somatic hypermutation within the immunoglobulin heavy chain gene locus using germinal center B cells from mouse Peyer’s patches.

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Keywords: Somatic Hypermutation JH4 Intron Germinal Center B Cells Peyer's Patches Antibody Diversification Molecular Biology PCR Sanger Sequencing Tissue Dissection Cell Isolation
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