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Rating L-DOPA-induceret dyskinesier i den ensidigt 6-OHDA-læsionerede rottemodel af Parkinsons sygdom
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Journal JoVE Biologie
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson’s Disease

Rating L-DOPA-induceret dyskinesier i den ensidigt 6-OHDA-læsionerede rottemodel af Parkinsons sygdom

DOI:
10.3791/62924-v

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06:45 min

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October 04, 2021

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, , ,
1Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto,University of São Paulo

Chapitres

  • 00:04Introduction
  • 00:496-Hydroxydopamine (6-OHDA) Lesion
  • 03:12L-Dopamine (L-DOPA) Chronic Treatment and Abnormal Involuntary Movements (AIMs) Recording and Scoring
  • 05:27Results: The AIMs Patterns in Unilaterally 6-OHDA-Lesioned Rats Chronically Treated with L-DOPA for 3 Weeks
  • 06:16Conclusion

Summary

Traduction automatique

Traduction automatique

Gnavermodeller af L-DOPA-inducerede dyskinesier er uvurderlige værktøjer til at identificere terapeutiske interventioner for at dæmpe udviklingen eller lindre de manifestationer, der opstår på grund af gentagen administration af L-DOPA. Denne protokol demonstrerer, hvordan man inducerer og analyserer dyskinetisk-lignende bevægelser i den ensidigt 6-OHDA-læsionerede rottemodel af Parkinsons sygdom.

Tags

Keywords: 6-OHDAParkinson’s DiseaseL-DOPA-induced DyskinesiasRat ModelStereotaxic SurgeryStepping TestAbnormal Involuntary Movements

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