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Analyse af Parkinsons sygdom musemodel induceret af Adeno-associerede virale vektorer, der koder for humane α-synuclein
Journal JoVE
Neurosciences
Author Produced
This content is Free Access.
Journal JoVE Neurosciences
Analyzing the Parkinson’s Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
DOI:

14:45 min

July 29, 2022

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Chapitres

  • 00:13Introduction
  • 02:25The Stereotaxic Surgery
  • 05:38Determination of the Motor Performance Using the Beam Test
  • 07:00Tissue Processing
  • 08:51Representative Results
  • 12:59Conclusion

Summary

Traduction automatique

Dette arbejde analyserer vektordosis og eksponeringstid, der kræves for at inducere neuroinflammation, neurodegeneration og motorisk svækkelse i denne prækliniske model af Parkinsons sygdom. Disse vektorer, der koder for den humane α-synuclein, leveres i substantia nigra for at rekapitulere synucleinpatologien forbundet med Parkinsons sygdom.

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