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Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
Journal JoVE
Médecine
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Journal JoVE Médecine
Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
DOI:

10:18 min

February 01, 2022

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Chapitres

  • 00:04Introduction
  • 00:54Preparation for Surgery
  • 01:37Permanent Ligation of the Right Coronary Artery
  • 03:03Echocardiographic Assessment of the RV (Right Ventricle) Function After Surgery
  • 05:25Invasive Measurements of RV Hemodynamic
  • 06:43Coronary Vascular Cast Using a Vascular Casting Agent
  • 07:49Results: Electrocardiography, Echocardiography and Histological Assessment After Right Coronary Artery Ligation
  • 09:48Conclusion

Summary

Traduction automatique

There are several differences between the right and left ventricles. However, the pathophysiology of right ventricular infarction (RVI) has not been clarified. In the present protocol, a reproducible method for RVI mouse model generation is introduced, which may provide a means to explain the mechanism of RVI.

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