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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
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Médecine
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Journal JoVE Médecine
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

DOI:
10.3791/63526-v

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07:09 min

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February 18, 2022

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, , , , , , , ,
1Guangdong Laboratory Animals Monitoring Institute, 2Department of Cardiovascular Surgery,the First Affiliated Hospital, Jinan University, 3College of Veterinary Medicine,South China Agricultural University

Chapitres

  • 00:04Introduction
  • 01:23Sedation, Tracheal Intubation, and Vein Cannulation
  • 02:10Surgical Procedure
  • 03:41Transthoracic Echocardiography
  • 04:51Results: Heart Failure with Preserved Ejection Fraction
  • 06:51Conclusion

Summary

Traduction automatique

Traduction automatique

The present protocol describes a step-by-step procedure to establish a minipig model of heart failure with preserved ejection fraction using descending aortic constriction. The methods for evaluating cardiac morphology, histology, and function of this disease model are also presented.

Tags

Heart FailureHFpEFTibetan MinipigsSurgical ModelAortic ConstrictionPressure OverloadEchocardiographyAnimal CareSurgical TechniqueAnesthesiaMonitoring

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