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基于泰勒鼠脑脊髓炎病毒的感染性病因癫痫模型

Journal JoVE
Neurosciences

This content is Free Access.

Journal JoVE Neurosciences

A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus

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基于泰勒鼠脑脊髓炎病毒的感染性病因癫痫模型

DOI:

10.3791/63673-v

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05:33 min

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June 23, 2022

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Gaelle Batot, Cameron S. Metcalf, Laura A. Bell², Alberto Pauletti, Karen S. Wilcox², Sonja Bröer

¹Department of Pharmacology and Toxicology,University of Utah, ²Interdepartmental Program in Neuroscience,University of Utah, ³Faculty of Veterinary Medicine, Institute of Pharmacology and Toxicology,Freie Universität Berlin

Chapitres

00:05Introduction
00:56Virus Inoculation
02:45Seizure Monitoring of Handling‐Induced Seizures
03:29Results: Infection‐Based Rodent Model for Epilepsy to Investigate Acute and Chronic Seizure Development
04:41Conclusion

Summary

Traduction automatique

C57BL / 6小鼠中Theiler小鼠脑脊髓炎病毒（TMEV）的脑内感染复制了人类患者病毒性脑炎和随后癫痫的许多早期和慢性临床症状。本文描述了TMEV模型的病毒感染、症状和组织病理学。

Tags

Keywords: TMEV Model Epilepsy CNS Infection Experimental Model Virus Injection Theiler’s Murine Encephalomyelitis Virus Seizure Development Therapeutic Targets Graduate Student Injection Procedure Anesthesia Intracordical Injection Seizure Activity Modified Racine Scale

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