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Journal / Genetics / 跨长度尺度捕获染色体构象
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JoVE Journal Genetics
跨长度尺度捕获染色体构象
 
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跨长度尺度捕获染色体构象

Article DOI: 10.3791/64001-v • 10:15 min • January 20th, 2023
January 20th, 2023 •
1, 1, 1,2, 1
1Department of Systems Biology, University of Massachusetts Medical School, 2Howard Hughes Medical Institute

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Hi-C 3.0 是一种改进的 Hi-C 方案，它将甲醛和二琥珀酰亚胺戊二酸酯交联剂与 DpnII 和 DdeI 限制性内切酶的混合物相结合，以提高信噪比和染色质相互作用检测的分辨率。

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遗传学，第 191 期，染色体构象捕获、交联、限制性酶切、染色质环、点、拓扑关联结构域、区室化
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