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Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain
Journal JoVE
Neurosciences
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Journal JoVE Neurosciences
Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain

Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain

DOI:
10.3791/64079-v

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08:23 min

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March 31, 2023

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, , , , , , , , , , , , ,
1Department of Neurosurgery,Houston Methodist Research Institute, 2ClearPoint Neuro, 3Translational Imaging Center,Houston Methodist Research Institute

Chapitres

  • 00:15Introduction
  • 00:55Animal Positioning
  • 01:31Planning Surgical Insertion with MRI-Assisted Visualization Guidance
  • 02:24Securing the Stereotactic Frame and Adjusting Alignment Iteratively Through Software Projection
  • 03:55Drilling and Inserting the Cannula for Infusion
  • 05:41Monitoring the Infusion with Repeated MRI Scans
  • 06:31Representative Results
  • 07:15Conclusion

Summary

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The protocol presented here demonstrates stereotaxy to the pig brain using convection-enhanced infusions, with real-time magnetic resonance imaging (MRI) visualization guidance and real-time infusion distribution visualization.

Tags

Magnetic Resonance ImagingStereotaxyInfusionPig BrainNeurosurgical InterventionMRI-guided ProcedureAnimal PositioningSurgical PlanningStereotactic FrameTrajectory PlanningEntry PointTarget Point

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