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用于评估人iPSC来源心肌细胞结构和收缩变化的杂交细胞分析系统,用于临床前心脏风险评估
Journal JoVE
Bio-ingénierie
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Journal JoVE Bio-ingénierie
Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
DOI:

08:03 min

October 20, 2022

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Chapitres

  • 00:04Introduction
  • 00:53Plate Coating
  • 01:58Seeding of Human iPSC‐Derived Cardiomyocytes into Flexible 96‐Well Plates (Day 0)
  • 02:56Medium Exchange of Flexible 96‐Well Plates (Day 1)
  • 03:53Final Medium Exchange Before Compound Addition (Day 5–7)
  • 04:21Compound Addition and Data Recording (Day 5–7)
  • 05:47Results: Contractility Assessment, Base Impedance, and EFP Recordings of Human iPSC‐Derived Cardiomyocytes After Drug Treatment
  • 07:35Conclusion

Summary

Traduction automatique

分析人iPSC来源的心肌细胞的收缩功能和细胞完整性的变化对于非临床药物开发具有重要意义。混合 96 孔细胞分析系统以实时和生理方式处理这两个参数,以获得可靠的、与人类相关的结果,这是安全过渡到临床阶段所必需的。

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