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Intrakraniel kanyleimplantation til serielle lokoregionale kimære antigenreceptor (CAR) T-celleinfusioner hos mus
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1Division of Oncology,Children’s Hospital of Philadelphia, 2Center for Data Driven Discovery in Biomedicine,Children’s Hospital of Philadelphia, 3Division of Neurosurgery,Children’s Hospital of Philadelphia, 4Ben Towne Center for Childhood Cancer Research,Seattle Children’s Research Institute, 5Department of Pediatrics, Seattle Children’s Hospital,University of Washington
Chapitres
- 00:04Introduction
- 00:48Mouse Preparation and Surgery Procedure
- 03:47CAR T Cell Infusion
- 04:36Results: Efficacy of CAR T Cell Therapy
- 04:53Conclusion
Centralnervesystemet (CNS) tumorer er den største årsag til kræftrelateret død hos børn, og lokoregionale immunbaserede terapier testes i stigende grad for patienter i kliniske forsøg. Denne protokol beskriver metoder til lokoregional kanyleimplantation hos mus til præklinisk evaluering af immunterapeutiske infusioner rettet mod CNS-tumorer.
