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在大鼠模型中使用低强度聚焦超声破坏血脊髓屏障
Journal JoVE
Bio-ingénierie
This content is Free Access.
Journal JoVE Bio-ingénierie
Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
DOI:

09:03 min

March 10, 2023

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Chapitres

  • 00:04Introduction
  • 01:11Low‐Intensity Focused Ultrasound Assembly and Setup
  • 02:20Animal Preparation and Surgical Laminectomy
  • 03:38Target Localization Using Laser Guidance
  • 04:22Microbubble Administration
  • 05:27Spinal Cord Extraction, Tissue Processing, and Visualization of BSCB Disruption
  • 06:34Results: Confirmation of Target Localization and Evaluating BSCB Disruption by EBD Extravasation into the Spinal Cord
  • 08:17Conclusion

Summary

Traduction automatique

通过静脉注射微泡和应用低强度聚焦超声 (LIFU),可以成功实现血脊髓屏障 (BSCB) 的破坏。该协议详细介绍了在啮齿动物模型中使用LIFU打开BSCB,包括设备设置,微气泡注入,目标定位和BSCB破坏可视化。

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