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In Vivo Brain Tumor Modeling via Electroporation-Based Delivery of Plasmid DNA

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使用基于电穿孔的质粒DNA递送对体内脑肿瘤进行建模，以代表患者突变特征

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Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

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使用基于电穿孔的质粒DNA递送对体内脑肿瘤进行建模，以代表患者突变特征

In Vivo Brain Tumor Modeling via Electroporation-Based Delivery of Plasmid DNA

DOI:

10.3791/65286-v

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02:03 min

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June 23, 2023

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Katie B. Grausam*¹, Joshua J. Breunig*^1,2,3,4,5

¹Board of Governor’s Regenerative Medicine Institute,Cedars-Sinai Medical Center, ²Center for Neural Sciences in Medicine,Cedars-Sinai Medical Center, ³Department of Biomedical Sciences,Cedars-Sinai Medical Center, ⁴Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center, ⁵Department of Medicine, David Geffen School of Medicine,University of California, Los Angeles

Tags

Glioblastoma Brain Tumor In Vivo Modeling Electroporation Plasmid DNA Patient Mutation Signatures Immunocompetent Mouse Model Tumor Microenvironment Immunotherapy Autochthonous Tumor Growth Preclinical Trials DNA Plasmids Neural Precursor Cells MADR Method Somatic Mutagenesis Driver Mutations

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