/

Recherche en cancérologie

/

In Vivo Brain Tumor Modeling via Electroporation-Based Delivery of Plasmid DNA

/

Modellering af hjernetumorer in vivo ved hjælp af elektroporationsbaseret levering af plasmid-DNA, der repræsenterer patientmutationssignaturer

Journal JoVE
Recherche en cancérologie

Un abonnement à JoVE est nécessaire pour voir ce contenu. Connectez-vous ou commencez votre essai gratuit.

Journal JoVE Recherche en cancérologie

Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

Modellering af hjernetumorer in vivo ved hjælp af elektroporationsbaseret levering af plasmid-DNA, der repræsenterer patientmutationssignaturer

In Vivo Brain Tumor Modeling via Electroporation-Based Delivery of Plasmid DNA

DOI:

10.3791/65286-v

•

02:03 min

•

June 23, 2023

•

Katie B. Grausam*¹, Joshua J. Breunig*^1,2,3,4,5

¹Board of Governor’s Regenerative Medicine Institute,Cedars-Sinai Medical Center, ²Center for Neural Sciences in Medicine,Cedars-Sinai Medical Center, ³Department of Biomedical Sciences,Cedars-Sinai Medical Center, ⁴Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center, ⁵Department of Medicine, David Geffen School of Medicine,University of California, Los Angeles

Tags

Keywords: Glioblastoma Brain Tumor In Vivo Modeling Electroporation Plasmid DNA Patient Mutation Signatures Immunocompetent Mouse Model Tumor Microenvironment Immunotherapy Autochthonous Tumor Growth Preclinical Trials DNA Plasmids Neural Precursor Cells MADR Method Somatic Mutagenesis Driver Mutations

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

Modellering af hjernetumorer in vivo ved hjælp af elektroporationsbaseret levering af plasmid-DNA, der repræsenterer patientmutationssignaturer

Mikroinjektion af DNA-plasmidblanding i musehjerneventriklen

Elektroporationsbaserede DNA-plasmider levering for at inducere in vivo-mutationer i musen

Read Article