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Pathology Assessment of PN-MPNST Progression in the P0-GGF?3 Mouse Model
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Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
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Recherche en cancérologie
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Journal JoVE Recherche en cancérologie
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Pathology Assessment of PN-MPNST Progression in the P0-GGF?3 Mouse Model

DOI:
10.3791/65740-v

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01:31 min

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May 17, 2024

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, , ,
1Department of Pathology and Laboratory Medicine,Medical University of South Carolina, 2Hollings Cancer Center,Medical University of South Carolina

Tags

Malignant Peripheral Nerve Sheath TumorsGenetically Engineered Mouse ModelsNeurofibromatosis Type 1Plexiform NeurofibromasTumor MicroenvironmentTumor TransformationHistologyImmunohistochemistryGradingP0-GGF Beta3 MiceNeuregulin-1

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Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Identifying Neurofibromas and Malignant Peripheral Nerve Sheath Tumors (MPNSTs) in P0-GGFβ3 Mice

Preparing Hematoxylin and Eosin-Stained Sections of Grossly Visible Tumors

Identifying Potential Plexiform Neurofibromas (PNs) and Malignant Peripheral Nerve Sheath Tumors (MPNSTs) by Performing Special Stains to Confirm Diagnoses

Verifying the Identity of Early-Passage MPNST Cells and Allograft of Early-Passage Tumor Cells to Demonstrate Tumorigenicity

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