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Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes
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Journal JoVE Biologie
Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson’s Disease Genes

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

DOI:
10.3791/835-v

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08:42 min

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July 18, 2008

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, , , , ,
1Department of Biological Sciences,University of Alabama

Chapitres

  • 00:26Introduction
  • 01:44Performing Genetic Crosses for Dopamine Neurodegeneration Analysis
  • 03:51Performing Dopaminergic Neuron Analysis
  • 07:49Conclusion

Summary

Traduction automatique

Traduction automatique

This video demonstrates how to use C. elegans to assess dopaminergic neuron neurodegeneration as a model for Parkinson's disease. Furthermore, genetic screens are used to identify factors that either enhance degeneration or are neuroprotective.

Tags

C. ElegansDopamine Neuron Degeneration AssayParkinson’s Disease GenesDiagnosisTreatmentSusceptibility FactorsCandidate GenesPolymorphismsProteinsAnimal Model SystemCaenorhabditis ElegansDopamine NeuronsAlpha-synucleinNeurodegenerationGFPDA Transporter Promoter (Pdat-1)TorsinARNAi

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