Tabriz University View Institution's Website 4 articles published in JoVE Behavior Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain Hatef Khosravi1,2, Nasim Eskandari1,2, Benjamin Provencher1,2, Thierry Paquette1,2, Hugues Leblond1,2, Emad Khalilzadeh1,3, Mathieu Piché1,2 1Department of Anatomy, Université du Québec à Trois-Rivières, 2CogNAC Research Group, Université du Québec à Trois-Rivières, 3Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz To develop novel therapeutic interventions for the prevention and management of back pain, animal models are required to examine the mechanisms and effectiveness of these therapies from a translational perspective. The present protocol describes the BMS test, a standardized method to assess back mechanical sensitivity in the rat. Engineering Microfluidic Device for the Separation of Non-Metastatic (MCF-7) and Non-Tumor (MCF-10A) Breast Cancer Cells Using AC Dielectrophoresis Ateeq ur Rehman1, Rahman S. Zabibah2, Samira Kharratian3, Adil Mustafa4,5 1Department of Biomedical Engineering, Foundation University Islamabad, 2College of Medical Technology, The Islamic University Najaf, 3Faculty of Mechanical Engineering, University of Tabriz, 4Department of Engineering Mathematics, University of Bristol, 5School of Life Sciences, University of Warwick Breast cancer cells exhibit different dielectric properties compared to non-tumor breast epithelial cells. It has been hypothesized that, based on this difference in dielectric properties, the two populations can be separated for immunotherapy purposes. To support this, we model a microfluidic device to sort MCF-7 and MCF-10A cells. Neuroscience A Protocol for Transcranial Photobiomodulation Therapy in Mice Farzad Salehpour1,2, Luis De Taboada3, Paolo Cassano4,5,6, Farzin Kamari1, Javad Mahmoudi1, Sohrab Ahmadi-Kandjani7, Seyed Hossein Rasta8,9,10, Saeed Sadigh-Eteghad1 1Neurosciences Research Center, Tabriz University of Medical Sciences, 2ProNeuroLIGHT LLC, 3LiteCure LLC, 4Department of Psychiatry, Harvard Medical School, 5Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, 6Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, 7Research Institute for Applied Physics and Astronomy, University of Tabriz, 8Department of Medical Physics, Tabriz University of Medical Sciences, 9Department of Medical Bioengineering, Tabriz University of Medical Sciences, 10School of Medical Sciences, University of Aberdeen Photobiomodulation therapy is an innovative noninvasive modality for the treatment of a wide range of neurological and psychiatric disorders and can also improve healthy brain function. This protocol includes a step-by-step guide to performing brain photobiomodulation in mice by transcranial light delivery, which can be adapted for use in other laboratory rodents. Biology Cellular Toxicity of Nanogenomedicine in MCF-7 Cell Line: MTT assay Somaieh Ahmadian1,2, Jaleh Barar1,3, Amir Ata Saei1, Mohammad Amin Abolghassemi Fakhree2, Yadollah Omidi1,3 1Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University (Medical Sciences), 2Gifted and Talented Students Office, Educational Development Center, Tabriz University (Medical Sciences), 3School of Advanced Biomedical Sciences, Tabriz University (Medical Sciences) The MTT assay is an easy and reproducible colorimetric assay for evaluation of cell viability based on reduction of yellow MTT and production of water insoluble purple formazan. Here, the viability of MCF-7 cells upon treatment of nanogenomedicine has been evaluated.