Beijing Military General Hospital 1 article published in JoVE Developmental Biology A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome Ping Xue1, Zhiqiang Wang1, Xiaomin Fu1,2, Junjiang Wang1,3, Gopika Punchhi1, Andrew Wolfe1,4, Sheng Wu1,4,5 1Department of Pediatrics, Johns Hopkins University School of Medicine, 2Department of Health, Beijing Military General Hospital, 3Southern Medical University, 4Department of Molecular and Cellular Physiology, Johns Hopkins University School of Medicine, 5Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine We describe the development of a lean PCOS-like mouse model with dihydrotestosterone pellet to study the pathophysiology of PCOS and the offspring from these PCOS-like dams.