Julich Aachen Research Alliance (JARA) 1 article published in JoVE Engineering Hand Controlled Manipulation of Single Molecules via a Scanning Probe Microscope with a 3D Virtual Reality Interface Philipp Leinen1,2, Matthew F. B. Green1,2, Taner Esat1,2, Christian Wagner1,2, F. Stefan Tautz1,2, Ruslan Temirov1,2 1Peter Grünberg Institut (PGI-3), Forschungszentrum Jülich, 2Fundamentals of Future Information Technology, Jülich Aachen Research Alliance (JARA) We demonstrate the precise manipulation of individual organic molecules on a metal surface with the tip of a scanning probe microscope driven in 3D by the experimenter's hand using a motion capture system and fully immersive virtual reality goggles.