Johannes Gutenberg University Medical Center 1 article published in JoVE Behavior Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes Sarah Ayash1, Marianne Müller1,2, Ulrich Schmitt1 1Leibniz-Institute for Resilience Research, 2Translational Psychiatry, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University Medical Center The social threat-safety test allows a simultaneous assessment of social avoidance development as a measurement of aversive conditioned learning and social threat-safety discrimination ability, both utilized to identify stress-susceptible and stress-resilient individuals within a single group of chronically socially defeated male mice.