Institute of Functional Genomics 2 articles published in JoVE Medicine Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases Margarita Arango-Lievano1,2,3, Patrizia Giannoni1,2,3, Sylvie Claeysen1,2,3, Nicola Marchi1,2,3, Freddy Jeanneteau1,2,3 1Inserm, U1191, Institute of Functional Genomics, 2CNRS, UMR-5203, 3Université de Montpellier This manuscript describes a procedure to track the remodeling of the cerebrovasculature during amyloid plaque accumulation in vivo using longitudinal two-photon microscopy. A thinned-skull preparation enables the visualization of fluorescent dyes to assess the progression of cerebrovascular damage in a mouse model of Alzheimer's disease. Immunology and Infection Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy Caroline Bonnans*1,2, Marja Lohela*2, Zena Werb2 1Department of Oncology, INSERM U661, Functional Genomic Institute, 2Department of Anatomy, University of California By using transgenic reporter mice and injectable fluorescent labels, long-term intravital spinning disk confocal microscopy enables direct visualization of myeloid cell behavior into intestinal adenoma in the ApcMin/+ colorectal cancer model.