Brazilian Institute of Neuroscience and Neurotechnology 1 article published in JoVE Medicine Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies Rodrigo Menezes Forti1,2, Marilise Katsurayama2,3, Giovani Grisotti Martins1, Lenise Valler2,3, Andrés Quiroga1,2, Luiz Simioni1, Julien Menko4, Antonio L. E. Falcão3, Li Min Li2,5, Rickson C. Mesquita1,2 1Institute of Physics, University of Campinas, 2Brazilian Institute of Neuroscience and Neurotechnology, 3Clinical Hospital, University of Campinas, 4Department of Emergency Medicine, Albert Einstein College of Medicine, 5School of Medical Sciences, University of Campinas Presented here is a protocol for non-invasively monitoring cerebral hemodynamics of neurocritical patients in real-time and at the bedside using diffuse optics. Specifically, the proposed protocol uses a hybrid diffuse optical systems to detect and display real-time information on cerebral oxygenation, cerebral blood flow and cerebral metabolism.