David J. Marcinek Department of Radiology University of Washington Biography Publications Institution JoVE Articles David J. Marcinek has not added a biography. If you are David J. Marcinek and would like to personalize this page please email our Author Liaison for assistance. Publications Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes Diabetes. Mar, 2024 | Pubmed ID: 38551899 Childhood Adverse Life Events and Skeletal Muscle Mitochondrial Function Science Advances. Mar, 2024 | Pubmed ID: 38446898 Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA) Aging Cell. Feb, 2024 | Pubmed ID: 38332629 Energetics and Clinical Factors for the Time Required to Walk 400 m: The Study of Muscle, Mobility and Aging (SOMMA) Journal of the American Geriatrics Society. Apr, 2024 | Pubmed ID: 38243364 Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Apr, 2024 | Pubmed ID: 38150179 Lower Muscle Mitochondrial Energetics is Associated with Greater Phenotypic Frailty in Older Women and Men: the Study of Muscle, Mobility and Aging GeroScience. Apr, 2024 | Pubmed ID: 37987886 Mitochondrial Targeted Interventions for Aging Cold Spring Harbor Perspectives in Medicine. Mar, 2024 | Pubmed ID: 37788882 Older-aged C57BL/6 Mice Fed a Diet High in Saturated Fat and Sucrose for Ten Months Show Decreased Resilience to Aging Aging Pathobiology and Therapeutics. 2023 | Pubmed ID: 38706773 Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA) MedRxiv : the Preprint Server for Health Sciences. Nov, 2023 | Pubmed ID: 37986748 Age-related Changes of Skeletal Muscle Metabolic Response to Contraction Are Also Sex-dependent The Journal of Physiology. Sep, 2023 | Pubmed ID: 37742081 The Mitochondrially Targeted Peptide Elamipretide (SS-31) Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake Through the Adenine Nucleotide Translocator (ANT) GeroScience. Dec, 2023 | Pubmed ID: 37462785 A Novel Mitochondrial Complex I ROS Inhibitor Partially Improves Muscle Regeneration in Adult but Not Old Mice Redox Biology. Aug, 2023 | Pubmed ID: 37295159 Randomized Crossover Clinical Trial of Coenzyme Q10 and Nicotinamide Riboside in Chronic Kidney Disease JCI Insight. Jun, 2023 | Pubmed ID: 37159264 Skeletal Muscle Mitochondrial Interactome Remodeling is Linked to Functional Decline in Aged Female Mice Nature Aging. Mar, 2023 | Pubmed ID: 37118428 Age and Sex As Determinants of Acute Domoic Acid Toxicity in a Mouse Model Toxins. Apr, 2023 | Pubmed ID: 37104198 Intermittent Treatment with Elamipretide Preserves Exercise Tolerance in Aged Female Mice GeroScience. Aug, 2023 | Pubmed ID: 36840897 ATP and NAD Deficiency in Parkinson's Disease Nutrients. Feb, 2023 | Pubmed ID: 36839301 From Mitochondria to Cells to Humans: Targeting Bioenergetics in Aging and Disease The International Journal of Biochemistry & Cell Biology. Apr, 2023 | Pubmed ID: 36806357 The Multi-tissue Landscape of Somatic MtDNA Mutations Indicates Tissue-specific Accumulation and Removal in Aging ELife. Feb, 2023 | Pubmed ID: 36799304 Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake Through the Adenine Nucleotide Translocator (ANT) BioRxiv : the Preprint Server for Biology. Feb, 2023 | Pubmed ID: 36778398 The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Oct, 2023 | Pubmed ID: 36754371 DATP Elevation Induces Myocardial Metabolic Remodeling to Support Improved Cardiac Function Journal of Molecular and Cellular Cardiology. Feb, 2023 | Pubmed ID: 36470336 Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Aug, 2023 | Pubmed ID: 36462195 Aging Increases Susceptibility to Develop Cardiac Hypertrophy Following High Sugar Consumption Nutrients. Nov, 2022 | Pubmed ID: 36364920 Elamipretide Effects on the Skeletal Muscle Phosphoproteome in Aged Female Mice GeroScience. Dec, 2022 | Pubmed ID: 36322234 Long-term Treatment with Elamipretide Enhances Healthy Aging Phenotypes in Mice Aging Pathobiology and Therapeutics. 2022 | Pubmed ID: 36250163 Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial JAMA Network Open. Jan, 2022 | Pubmed ID: 35050355 An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice Investigative Ophthalmology & Visual Science. Nov, 2021 | Pubmed ID: 34797906 Ice Seals As Sentinels for Algal Toxin Presence in the Pacific Arctic and Subarctic Marine Ecosystems Marine Mammal Science. Oct, 2021 | Pubmed ID: 34690417 A Replication-linked Mutational Gradient Drives Somatic Mutation Accumulation and Influences Germline Polymorphisms and Genome Composition in Mitochondrial DNA Nucleic Acids Research. Nov, 2021 | Pubmed ID: 34614167 Elamipretide (SS-31) Treatment Attenuates Age-associated Post-translational Modifications of Heart Proteins GeroScience. Oct, 2021 | Pubmed ID: 34480713 In Vivo Mitochondrial ATP Production is Improved in Older Adult Skeletal Muscle After a Single Dose of Elamipretide in a Randomized Trial PloS One. 2021 | Pubmed ID: 34264994 Astaxanthin Supplementation Enhances Metabolic Adaptation with Aerobic Training in the Elderly Physiological Reports. Jun, 2021 | Pubmed ID: 34110707 Are Fat and Sugar Just As Detrimental in Old Age? GeroScience. Aug, 2021 | Pubmed ID: 34101101 High Intensity Muscle Stimulation Activates a Systemic Nrf2-mediated Redox Stress Response Free Radical Biology & Medicine. Aug, 2021 | Pubmed ID: 34089788 Reduction of Elevated Proton Leak Rejuvenates Mitochondria in the Aged Cardiomyocyte ELife. Dec, 2020 | Pubmed ID: 33319746 Increased Tumour Burden Alters Skeletal Muscle Properties in the KPC Mouse Model of Pancreatic Cancer JCSM Rapid Communications. 2020 | Pubmed ID: 33073264 SS-31 and NMN: Two Paths to Improve Metabolism and Function in Aged Hearts Aging Cell. Oct, 2020 | Pubmed ID: 32779818 Mitochondrial Protein Interaction Landscape of SS-31 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2020 | Pubmed ID: 32554501 Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor Toxins. May, 2019 | Pubmed ID: 31126088 Improving Mitochondrial Function with SS-31 Reverses Age-related Redox Stress and Improves Exercise Tolerance in Aged Mice Free Radical Biology & Medicine. 04, 2019 | Pubmed ID: 30597195 Repeated Low Level Domoic Acid Exposure Increases CA1 VGluT1 Levels, but Not Bouton Density, VGluT2 or VGAT Levels in the Hippocampus of Adult Mice Harmful Algae. Nov, 2018 | Pubmed ID: 30420019 Domoic Acid in California Sea Lion Fetal Fluids Indicates Continuous Exposure to a Neuroteratogen Poses Risks to Mammals Harmful Algae. Nov, 2018 | Pubmed ID: 30420016 Building Strength, Endurance, and Mobility Using an Astaxanthin Formulation with Functional Training in Elderly Journal of Cachexia, Sarcopenia and Muscle. Oct, 2018 | Pubmed ID: 30259703 Fatiguing Contractions Increase Protein S-glutathionylation Occupancy in Mouse Skeletal Muscle Redox Biology. 07, 2018 | Pubmed ID: 29857311 Cyclophosphamide Leads to Persistent Deficits in Physical Performance and in Vivo Mitochondria Function in a Mouse Model of Chemotherapy Late Effects PloS One. 2017 | Pubmed ID: 28700655 Effect of Contaminants of Emerging Concern on Liver Mitochondrial Function in Chinook Salmon Aquatic Toxicology (Amsterdam, Netherlands). Sep, 2017 | Pubmed ID: 28668760 Chronic Low-level Exposure to the Common Seafood Toxin Domoic Acid Causes Cognitive Deficits in Mice Harmful Algae. Apr, 2017 | Pubmed ID: 28427569 Mitochondrial Protein Interactome Elucidated by Chemical Cross-linking Mass Spectrometry Proceedings of the National Academy of Sciences of the United States of America. Feb, 2017 | Pubmed ID: 28130547 Acute and Chronic Dietary Exposure to Domoic Acid in Recreational Harvesters: A Survey of Shellfish Consumption Behavior Environment International. Apr, 2017 | Pubmed ID: 28109640 The Mitochondrial-targeted Peptide, SS-31, Improves Glomerular Architecture in Mice of Advanced Age Kidney International. May, 2017 | Pubmed ID: 28063595 Skeletal Muscle Bioenergetics in Aging and Heart Failure Heart Failure Reviews. Mar, 2017 | Pubmed ID: 27815651 Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through CGMP-Dependent Mechanisms Antioxidants & Redox Signaling. Jun, 2017 | Pubmed ID: 27393340 NAD+ Repletion Improves Muscle Function in Muscular Dystrophy and Counters Global PARylation Science Translational Medicine. Oct, 2016 | Pubmed ID: 27798264 Evaluation of in Vivo Mitochondrial Bioenergetics in Skeletal Muscle Using NMR and Optical Methods Biochimica Et Biophysica Acta. Apr, 2016 | Pubmed ID: 26708941 Age Modifies Respiratory Complex I and Protein Homeostasis in a Muscle Type-specific Manner Aging Cell. Feb, 2016 | Pubmed ID: 26498839 Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury Toxicological Sciences : an Official Journal of the Society of Toxicology. Jan, 2016 | Pubmed ID: 26494550 The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function Frontiers in Physiology. 2015 | Pubmed ID: 26635632 Effect of Omega-3 Fatty Acid Oxidation Products on the Cellular and Mitochondrial Toxicity of BDE 47 Toxicology in Vitro : an International Journal Published in Association with BIBRA. Jun, 2015 | Pubmed ID: 25659769 In Vivo Metabolic Spectroscopy Identifies Deficits in Mitochondrial Quality and Capacity in Aging Skeletal Muscle Clinical Pharmacology and Therapeutics. Dec, 2014 | Pubmed ID: 25207702 Chronic Low-level Domoic Acid Exposure Alters Gene Transcription and Impairs Mitochondrial Function in the CNS Aquatic Toxicology (Amsterdam, Netherlands). Oct, 2014 | Pubmed ID: 25033243 Mitochondrial Oxidative Stress in Aging and Healthspan Longevity & Healthspan. 2014 | Pubmed ID: 24860647 Targeting Redox Biology to Reverse Mitochondrial Dysfunction Aging. Aug, 2013 | Pubmed ID: 23945201 Mitochondrial-targeted Peptide Rapidly Improves Mitochondrial Energetics and Skeletal Muscle Performance in Aged Mice Aging Cell. Oct, 2013 | Pubmed ID: 23692570 Higher Mitochondrial Respiration and Uncoupling with Reduced Electron Transport Chain Content in Vivo in Muscle of Sedentary Versus Active Subjects The Journal of Clinical Endocrinology and Metabolism. Jan, 2013 | Pubmed ID: 23150693 Defects in Mitochondrial Localization and ATP Synthesis in the Mdx Mouse Model of Duchenne Muscular Dystrophy Are Not Alleviated by PDE5 Inhibition Human Molecular Genetics. Jan, 2013 | Pubmed ID: 23049075 Impaired Adaptability of in Vivo Mitochondrial Energetics to Acute Oxidative Insult in Aged Skeletal Muscle Mechanisms of Ageing and Development. 2012 | Pubmed ID: 22935551 A Novel Antibody-based Biomarker for Chronic Algal Toxin Exposure and Sub-acute Neurotoxicity PloS One. 2012 | Pubmed ID: 22567140 Reduced Coupling of Oxidative Phosphorylation in Vivo Precedes Electron Transport Chain Defects Due to Mild Oxidative Stress in Mice PloS One. 2011 | Pubmed ID: 22132085 Mitochondrial Oxidative Stress Mediates Angiotensin II-induced Cardiac Hypertrophy and Galphaq Overexpression-induced Heart Failure Circulation Research. Apr, 2011 | Pubmed ID: 21311045 Age-dependent Cardiomyopathy in Mitochondrial Mutator Mice is Attenuated by Overexpression of Catalase Targeted to Mitochondria Aging Cell. Aug, 2010 | Pubmed ID: 20456298 Lactic Acidosis in Vivo: Testing the Link Between Lactate Generation and H+ Accumulation in Ischemic Mouse Muscle Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2010 | Pubmed ID: 20133437 Mitochondrial Function in Vivo: Spectroscopy Provides Window on Cellular Energetics Methods (San Diego, Calif.). Dec, 2008 | Pubmed ID: 18930151 Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy Cell Metabolism. Apr, 2008 | Pubmed ID: 18396137 Mitochondrial Dysfunction and Age Current Opinion in Clinical Nutrition and Metabolic Care. Nov, 2007 | Pubmed ID: 18089948 Wavelength Shift Analysis: a Simple Method to Determine the Contribution of Hemoglobin and Myoglobin to in Vivo Optical Spectra Applied Spectroscopy. Jun, 2007 | Pubmed ID: 17650380 Mitochondrial Dysfunction: Impact on Exercise Performance and Cellular Aging Exercise and Sport Sciences Reviews. Apr, 2007 | Pubmed ID: 17417049 Mild Mitochondrial Uncoupling Impacts Cellular Aging in Human Muscles in Vivo Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17215370 Mitochondrial Function, Fibre Types and Ageing: New Insights from Human Muscle in Vivo Experimental Physiology. Mar, 2007 | Pubmed ID: 17170059 Reduced Mitochondrial Coupling in Vivo Alters Cellular Energetics in Aged Mouse Skeletal Muscle The Journal of Physiology. Dec, 2005 | Pubmed ID: 16254011 Mitochondrial Coupling in Vivo in Mouse Skeletal Muscle American Journal of Physiology. Cell Physiology. Feb, 2004 | Pubmed ID: 14522819 Oxygen Regulation and Limitation to Cellular Respiration in Mouse Skeletal Muscle in Vivo American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2003 | Pubmed ID: 12775561 Basal Glycogenolysis in Mouse Skeletal Muscle: in Vitro Model Predicts in Vivo Fluxes Molecular Biology Reports. 2002 | Pubmed ID: 12241044 Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry Ana P. Valencia1, Gavin Pharaoh2, Arthur F. Brandao1, David J. Marcinek2,3 1Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, 2Department of Radiology, University of Washington, 3Department of Laboratory Medicine and Pathology, University of Washington JoVE 66863 Biologia
Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry Ana P. Valencia1, Gavin Pharaoh2, Arthur F. Brandao1, David J. Marcinek2,3 1Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, 2Department of Radiology, University of Washington, 3Department of Laboratory Medicine and Pathology, University of Washington JoVE 66863 Biologia