Hansjürgen Agostini Eye Center, Medical Center - University of Freiburg, Faculty of Medicine University of Freiburg Biography Publications Institution JoVE Articles Hansjürgen Agostini has not added a biography. If you are Hansjürgen Agostini and would like to personalize this page please email our Author Liaison for assistance. Publications Early REperfusion Therapy with Intravenous Alteplase for Recovery of VISION in Acute Central Retinal Artery Occlusion (REVISION): Study Protocol of a Phase III Trial International Journal of Stroke : Official Journal of the International Stroke Society. Apr, 2024 | Pubmed ID: 38591748 Psychometric Assessment of Patients with Central Serous Chorioretinopathy and Correlation with Disease Stage and Progression: a Case Control Study BMC Ophthalmology. Feb, 2024 | Pubmed ID: 38424605 Clinical Landscape of Central Serous Chorioretinopathy in Germany: Retina.net CSC Registry Report Number 1 Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde. 2024 | Pubmed ID: 38368867 2D and 3D in Vitro Angiogenesis Assays Highlight Different Aspects of Angiogenesis Biochimica Et Biophysica Acta. Molecular Basis of Disease. Mar, 2024 | Pubmed ID: 38244944 Oncostatin M Reduces Pathological Neovascularization in the Retina Through Müller Cell Activation Investigative Ophthalmology & Visual Science. Jan, 2024 | Pubmed ID: 38190125 LASER FLARE PHOTOMETRY IN PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT: An Evaluation of 2,487 Cases Retina (Philadelphia, Pa.). May, 2024 | Pubmed ID: 38181515 Addressing Bias in Manual Segmentation of Spheroid Sprouting Assays with U-Net Molecular Vision. 2023 | Pubmed ID: 38222450 Transcriptional Comparison of Human and Murine Retinal Neovascularization Investigative Ophthalmology & Visual Science. Dec, 2023 | Pubmed ID: 38153746 STAT3 Signaling Induced by the IL-6 Family of Cytokines Modulates Angiogenesis Journal of Cell Science. Jan, 2023 | Pubmed ID: 36458801 Web-based Gene Expression Analysis-paving the Way to Decode Healthy and Diseased Ocular Tissue Die Ophthalmologie. Jan, 2023 | Pubmed ID: 36098765 [Pandemic-related Sales Ban of Fireworks in Germany Leads to A significant Reduction of Firework-related Eye Injuries] Die Ophthalmologie. Dec, 2022 | Pubmed ID: 36449087 Methylglyoxal and High Glucose Inhibit VEGFR2 Phosphorylation at Specific Tyrosine Residues Zeitschrift Fur Naturforschung. C, Journal of Biosciences. Nov, 2022 | Pubmed ID: 35767310 Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy: Results from a Randomized Clinical Trial Ophthalmology. Oct, 2022 | Pubmed ID: 35680097 Single-Cell Protein and Transcriptional Characterization of Epiretinal Membranes From Patients With Proliferative Vitreoretinopathy Investigative Ophthalmology & Visual Science. May, 2022 | Pubmed ID: 35579905 NAMD: Optimization of Patient Care and Patient-oriented Information with the Help of an Internet-based Survey Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Oct, 2022 | Pubmed ID: 35552499 Transcriptional and Distributional Profiling of Microglia in Retinal Angiomatous Proliferation International Journal of Molecular Sciences. Mar, 2022 | Pubmed ID: 35408803 In-Depth Molecular Profiling Specifies Human Retinal Microglia Identity Frontiers in Immunology. 2022 | Pubmed ID: 35371110 Deciphering the Molecular Signature of Human Hyalocytes in Relation to Other Innate Immune Cell Populations Investigative Ophthalmology & Visual Science. Mar, 2022 | Pubmed ID: 35266958 A Model to Quantify the Influence of Treatment Patterns and Optimize Outcomes in NAMD Scientific Reports. Feb, 2022 | Pubmed ID: 35181697 The Human Eye Transcriptome Atlas: A Searchable Comparative Transcriptome Database for Healthy and Diseased Human Eye Tissue Genomics. Mar, 2022 | Pubmed ID: 35124170 Comparative Transcriptome Analysis of Human and Murine Choroidal Neovascularization Identifies Fibroblast Growth Factor Inducible-14 As Phylogenetically Conserved Mediator of Neovascular Age-related Macular Degeneration Biochimica Et Biophysica Acta. Molecular Basis of Disease. Apr, 2022 | Pubmed ID: 35032596 Subretinal Fibrosis in Neovascular Age-related Macular Degeneration: Current Concepts, Therapeutic Avenues, and Future Perspectives Cell and Tissue Research. Mar, 2022 | Pubmed ID: 34477966 Characterization of the Cellular Microenvironment and Novel Specific Biomarkers in Pterygia Using RNA Sequencing Frontiers in Medicine. 2021 | Pubmed ID: 35174178 Immunosenescence in Choroidal Neovascularization (CNV)-Transcriptional Profiling of Naïve and CNV-Associated Retinal Myeloid Cells During Aging International Journal of Molecular Sciences. Dec, 2021 | Pubmed ID: 34948115 Viral S Protein Histochemistry Reveals Few Potential SARS-CoV-2 Entry Sites in Human Ocular Tissues Scientific Reports. Sep, 2021 | Pubmed ID: 34580409 The Role of Interferon Regulatory Factor 8 for Retinal Tissue Homeostasis and Development of Choroidal Neovascularisation Journal of Neuroinflammation. Sep, 2021 | Pubmed ID: 34544421 Imaging Mass Cytometry for High-dimensional Tissue Profiling in the Eye BMC Ophthalmology. Sep, 2021 | Pubmed ID: 34544377 Correction To: Surgical Outcomes in Patients with Optic Disc Pit Maculopathy: Does Peeling the ILM Lead to Better Outcomes? International Ophthalmology. Oct, 2021 | Pubmed ID: 34491489 Epileptic Seizure? Certainly Uncertain Documenta Ophthalmologica. Advances in Ophthalmology. Jun, 2021 | Pubmed ID: 33929689 Real-life Medium Term Follow-up Data for Intravitreal Dexamethasone Implant in Retinal Vein Occlusion Scientific Reports. Apr, 2021 | Pubmed ID: 33859243 Seizure Triggered by Flicker Electroretinogram in a Patient with No History of Epilepsy Documenta Ophthalmologica. Advances in Ophthalmology. Jun, 2021 | Pubmed ID: 33355884 Two-Year Results of the Phase 3 Randomized Controlled Study of Abicipar in Neovascular Age-Related Macular Degeneration Ophthalmology. Jul, 2021 | Pubmed ID: 33221326 Arteriovenous Crossing in Retinal Vessels of Mice, Rats, and Pigs Molecular Vision. 2020 | Pubmed ID: 33273800 Transcriptional Characterization of Conjunctival Melanoma Identifies the Cellular Tumor Microenvironment and Prognostic Gene Signatures Scientific Reports. Oct, 2020 | Pubmed ID: 33046735 Transcriptional Profiling Uncovers Human Hyalocytes As a Unique Innate Immune Cell Population Frontiers in Immunology. 2020 | Pubmed ID: 33042148 CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10 Investigative Ophthalmology & Visual Science. 08, 2020 | Pubmed ID: 32780864 Surgical Outcomes in Patients with Optic Disc Pit Maculopathy: Does Peeling the ILM Lead to Better Outcomes? International Ophthalmology. Dec, 2020 | Pubmed ID: 32737732 Hemangioblastoma and Von Hippel-Lindau Disease: Genetic Background, Spectrum of Disease, and Neurosurgical Treatment Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery. Oct, 2020 | Pubmed ID: 32507909 Efficacy and Safety of Abicipar in Neovascular Age-Related Macular Degeneration: 52-Week Results of Phase 3 Randomized Controlled Study Ophthalmology. Oct, 2020 | Pubmed ID: 32471729 3' MACE RNA-sequencing Allows for Transcriptome Profiling in Human Tissue Samples After Long-term Storage Laboratory Investigation; a Journal of Technical Methods and Pathology. Oct, 2020 | Pubmed ID: 32467590 Expression of the COVID-19 Receptor ACE2 in the Human Conjunctiva Journal of Medical Virology. Oct, 2020 | Pubmed ID: 32374427 Transcriptomic Characterization of Human Choroidal Neovascular Membranes Identifies Calprotectin As a Novel Biomarker for Patients with Age-Related Macular Degeneration The American Journal of Pathology. Aug, 2020 | Pubmed ID: 32339498 Temporospatial Distribution and Transcriptional Profile of Retinal Microglia in the Oxygen-induced Retinopathy Mouse Model Glia. Sep, 2020 | Pubmed ID: 32150307 [Experienced Quality Assurance in the IVOM Structural Contract Of the AOK‑BW : A Practical Example] Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft. Apr, 2020 | Pubmed ID: 32108251 Comparison of the Efficacy of Brolucizumab with Natural Disease Progression in Wet AMD Using Clinical Data from the Phase III HAWK and HARRIER Trials and Modelled Placebo Data Current Eye Research. Oct, 2020 | Pubmed ID: 32065533 Longitudinal Analysis of the Choriocapillaris Using Optical Coherence Tomography Angiography Reveals Subretinal Fluid As a Substantial Confounder in Patients with Acute Central Serous Chorioretinopathy Ophthalmology and Therapy. Dec, 2019 | Pubmed ID: 31654333 Anti-VEGF Injection Frequency Correlates with Visual Acuity Outcomes in Pro Re Nata Neovascular AMD Treatment Scientific Reports. Mar, 2019 | Pubmed ID: 30824721 OCT Angiography of the Choriocapillaris in Central Serous Chorioretinopathy: A Quantitative Subgroup Analysis Ophthalmology and Therapy. Mar, 2019 | Pubmed ID: 30617944 Semaphorin 3F Modulates Corneal Lymphangiogenesis and Promotes Corneal Graft Survival Investigative Ophthalmology & Visual Science. Oct, 2018 | Pubmed ID: 30383199 Vitrectomy with and Without Encircling Band for Pseudophakic Retinal Detachment with Inferior Breaks: VIPER Study Report No. 3 Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Nov, 2018 | Pubmed ID: 30140963 Gene Expression Profiling in a Mouse Model of Retinal Vein Occlusion Induced by Laser Treatment Reveals a Predominant Inflammatory and Tissue Damage Response PloS One. 2018 | Pubmed ID: 29529099 Association of Treatment Adherence with Real-life VA Outcomes in AMD, DME, and BRVO Patients Clinical Ophthalmology (Auckland, N.Z.). 2018 | Pubmed ID: 29339917 Potential Selection Bias in Candidates for Stereotactic Radiotherapy for Neovascular AMD Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Jan, 2018 | Pubmed ID: 29168044 [Prognosis and Treatment of Macular Bleeding in Neovascular Age-related Macular Degeneration] Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft. May, 2017 | Pubmed ID: 28405758 Sema3f Protects Against Subretinal Neovascularization In Vivo EBioMedicine. Apr, 2017 | Pubmed ID: 28373097 Vitrectomy with and Without Encircling Band for Pseudophakic Retinal Detachment: VIPER Study Report No 2-main Results The British Journal of Ophthalmology. Jun, 2017 | Pubmed ID: 27609785 Five-year Visual Acuity Outcomes and Injection Patterns in Patients with Pro-re-nata Treatments for AMD, DME, RVO and Myopic CNV The British Journal of Ophthalmology. Mar, 2017 | Pubmed ID: 27215744 Initiation of Intravitreal Aflibercept Injection Treatment in Patients with Diabetic Macular Edema: a Review of VIVID-DME and VISTA-DME Data International Journal of Retina and Vitreous. 2016 | Pubmed ID: 27847634 Systemic Confounders Affecting Serum Measurements of Omega-3 and -6 Polyunsaturated Fatty Acids in Patients with Retinal Disease BMC Ophthalmology. Sep, 2016 | Pubmed ID: 27596098 CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy Investigative Ophthalmology & Visual Science. Aug, 2016 | Pubmed ID: 27494343 Clinical Experience with Eplerenone to Treat Chronic Central Serous Chorioretinopathy Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Nov, 2016 | Pubmed ID: 27145785 Patient Preferences in the Treatment of Neovascular Age-Related Macular Degeneration: A Discrete Choice Experiment Ophthalmology. Apr, 2016 | Pubmed ID: 26778346 Autophagy Activation Clears ELAVL1/HuR-mediated Accumulation of SQSTM1/p62 During Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells PloS One. 2013 | Pubmed ID: 23922739 In Vivo Imaging of Choroidal Angiogenesis Using Fluorescence-labeled Cationic Liposomes Molecular Vision. 2012 | Pubmed ID: 22605917 [Anti-angiogenic Therapy in Ocular Disease--current and Future Strategies] Klinische Monatsblatter Fur Augenheilkunde. Jan, 2008 | Pubmed ID: 18236368 [Treatment of Pseudophakic Cystoid Macular Edema] Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft. May, 2007 | Pubmed ID: 17443332 Bevacizumab in Retinal Vein Occlusion-results of a Prospective Case Series Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Oct, 2007 | Pubmed ID: 17356824 A Single Local Injection of Recombinant VEGF Receptor 2 but Not of Tie2 Inhibits Retinal Neovascularization in the Mouse Current Eye Research. Apr, 2005 | Pubmed ID: 15823917 Genotypes of JC Virus, DNA of Cytomegalovirus, and Proviral DNA of Human Immunodeficiency Virus in Eyes of Acquired Immunodeficiency Syndrome Patients Journal of Neurovirology. Feb, 2005 | Pubmed ID: 15804960 Intravitreal Injection of Specific Receptor Tyrosine Kinase Inhibitor PTK787/ZK222 584 Improves Ischemia-induced Retinopathy in Mice Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Jun, 2005 | Pubmed ID: 15650859 Local Injection of Receptor Tyrosine Kinase Inhibitor MAE 87 Reduces Retinal Neovascularization in Mice Molecular Vision. Jul, 2004 | Pubmed ID: 15273654 Genotypes of JC Virus in East, Central and Southwest Europe The Journal of General Virology. May, 2001 | Pubmed ID: 11297697 Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay Julian Rapp*1,2, Jan Ness*1,3, Paula Liang1, Martin J. Hug4, Hansjürgen Agostini1, Günther Schlunck1, Clemens Lange5, Felicitas Bucher1 1Eye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 2Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 3Institute of Pharmaceutical Sciences, Faculty of Chemistry and Pharmacy, University of Freiburg, 4Pharmacy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 5Ophtha-Lab, Department of Ophthalmology, St. Franziskus Hospital Muenster JoVE 66954 Medicina
Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay Julian Rapp*1,2, Jan Ness*1,3, Paula Liang1, Martin J. Hug4, Hansjürgen Agostini1, Günther Schlunck1, Clemens Lange5, Felicitas Bucher1 1Eye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 2Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 3Institute of Pharmaceutical Sciences, Faculty of Chemistry and Pharmacy, University of Freiburg, 4Pharmacy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 5Ophtha-Lab, Department of Ophthalmology, St. Franziskus Hospital Muenster JoVE 66954 Medicina