Jay Unruh Stowers Institute for Medical Research Biography Publications Institution JoVE Articles Jay Unruh has not added a biography. If you are Jay Unruh and would like to personalize this page please email our Author Liaison for assistance. Publications Tumor-initiating Stem Cell Shapes Its Microenvironment into an Immunosuppressive Barrier and Pro-tumorigenic Niche Cell Reports. Sep, 2021 | Pubmed ID: 34496236 Multiple Roles for PARP1 in ALC1-dependent Nucleosome Remodeling Proceedings of the National Academy of Sciences of the United States of America. Sep, 2021 | Pubmed ID: 34465625 Proteome Plasticity in Response to Persistent Environmental Change Molecular Cell. 08, 2021 | Pubmed ID: 34293321 Redistribution of Centrosomal Proteins by Centromeres and Polo Kinase Controls Partial Nuclear Envelope Breakdown in Fission Yeast Molecular Biology of the Cell. 08, 2021 | Pubmed ID: 34133218 A Role for the Cockayne Syndrome B (CSB)-Elongin Ubiquitin Ligase Complex in Signal-dependent RNA Polymerase II Transcription The Journal of Biological Chemistry. 07, 2021 | Pubmed ID: 34116057 Super-resolution Microscopy-based Bimolecular Fluorescence Complementation to Study Protein Complex Assembly and Co-localization Bio-protocol. Feb, 2020 | Pubmed ID: 33654748 Driving Integrative Structural Modeling with Serial Capture Affinity Purification Proceedings of the National Academy of Sciences of the United States of America. 12, 2020 | Pubmed ID: 33257578 Orderly Assembly Underpinning Built-in Asymmetry in the Yeast Centrosome Duplication Cycle Requires Cyclin-dependent Kinase ELife. 08, 2020 | Pubmed ID: 32851976 β-Catenin and Associated Proteins Regulate Lineage Differentiation in Ground State Mouse Embryonic Stem Cells Stem Cell Reports. 09, 2020 | Pubmed ID: 32822591 Chromosome and Autosomal Recombination Are Differentially Sensitive to Disruptions in SC Maintenance Proceedings of the National Academy of Sciences of the United States of America. 10, 2019 | Pubmed ID: 31570610 Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo Cell. 09, 2019 | Pubmed ID: 31491385 PCP and Wnt Pathway Components Act in Parallel During Zebrafish Mechanosensory Hair Cell Orientation Nature Communications. 09, 2019 | Pubmed ID: 31488837 Superresolution Microscopy Reveals Linkages Between Ribosomal DNA on Heterologous Chromosomes The Journal of Cell Biology. 08, 2019 | Pubmed ID: 31270138 The Stoichiometry of the Outer Kinetochore is Modulated by Microtubule-proximal Regulatory Factors The Journal of Cell Biology. 07, 2019 | Pubmed ID: 31118239 Dopamine Receptor Antagonists As Potential Therapeutic Agents for ADPKD PloS One. 2019 | Pubmed ID: 31059522 Yeast Centrosome Components Form a Noncanonical LINC Complex at the Nuclear Envelope Insertion Site The Journal of Cell Biology. 05, 2019 | Pubmed ID: 30862629 Imaging-based Assays for Investigating Functions of the RNA Polymerase II Elongation Factor Elongin and the Elongin Ubiquitin Ligase Methods (San Diego, Calif.). Feb, 2019 | Pubmed ID: 30794906 Distribution of Proteins at the Inner Nuclear Membrane Is Regulated by the Asi1 E3 Ligase in Genetics. 04, 2019 | Pubmed ID: 30709848 N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells Cell Reports. 01, 2019 | Pubmed ID: 30650358 Functional Analysis of the Yeast LINC Complex Using Fluctuation Spectroscopy and Super-Resolution Imaging Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 30141044 Combined Expansion Microscopy with Structured Illumination Microscopy for Analyzing Protein Complexes Nature Protocols. 08, 2018 | Pubmed ID: 30072723 Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior Molecular Cell. 07, 2018 | Pubmed ID: 29979963 The Budding Yeast RSC Complex Maintains Ploidy by Promoting Spindle Pole Body Insertion The Journal of Cell Biology. 07, 2018 | Pubmed ID: 29875260 Integrative Structure and Functional Anatomy of a Nuclear Pore Complex Nature. 03, 2018 | Pubmed ID: 29539637 Structural Plasticity of the Living Kinetochore The Journal of Cell Biology. 11, 2017 | Pubmed ID: 28939613 HOXA1 and TALE Proteins Display Cross-regulatory Interactions and Form a Combinatorial Binding Code on HOXA1 Targets Genome Research. 09, 2017 | Pubmed ID: 28784834 Superresolution Expansion Microscopy Reveals the Three-dimensional Organization of the Synaptonemal Complex Proceedings of the National Academy of Sciences of the United States of America. 08, 2017 | Pubmed ID: 28760978 Ribosomal DNA Copy Number Loss and Sequence Variation in Cancer PLoS Genetics. Jun, 2017 | Pubmed ID: 28640831 Molecular Model of Fission Yeast Centrosome Assembly Determined by Superresolution Imaging The Journal of Cell Biology. 08, 2017 | Pubmed ID: 28619713 Dynamic Regulation of Nanog and Stem Cell-signaling Pathways by Hoxa1 During Early Neuro-ectodermal Differentiation of ES Cells Proceedings of the National Academy of Sciences of the United States of America. 06, 2017 | Pubmed ID: 28584089 Analysis of Membrane Proteins Localizing to the Inner Nuclear Envelope in Living Cells The Journal of Cell Biology. Nov, 2016 | Pubmed ID: 27831485 A Putative Biochemical Engram of Long-Term Memory Current Biology : CB. 12, 2016 | Pubmed ID: 27818176 WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage PloS One. 2016 | Pubmed ID: 27248496 Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation PLoS Biology. Jan, 2016 | Pubmed ID: 26812143 Intracellular Chloride Concentration of the Mouse Vomeronasal Neuron BMC Neuroscience. Dec, 2015 | Pubmed ID: 26667019 Karyotyping Human and Mouse Cells Using Probes from Single-sorted Chromosomes and Open Source Software BioTechniques. Dec, 2015 | Pubmed ID: 26651513 Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator Cell. Dec, 2015 | Pubmed ID: 26638074 Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II Via Transcriptional Elongation Control in Mitosis Molecular Cell. Nov, 2015 | Pubmed ID: 26527278 Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152 Genetics. Dec, 2015 | Pubmed ID: 26510791 Vilya, a Component of the Recombination Nodule, is Required for Meiotic Double-strand Break Formation in Drosophila ELife. Oct, 2015 | Pubmed ID: 26452093 Structured Illumination with Particle Averaging Reveals Novel Roles for Yeast Centrosome Components During Duplication ELife. Sep, 2015 | Pubmed ID: 26371506 Analysis of Dynamic Changes in Retinoid-induced Transcription and Epigenetic Profiles of Murine Hox Clusters in ES Cells Genome Research. Aug, 2015 | Pubmed ID: 26025802 Imaging Methodologies for Systems Biology Cell Adhesion & Migration. 2014 | Pubmed ID: 25482526 Organelle-based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells Cell. Oct, 2014 | Pubmed ID: 25417105 The Membrane-associated Proteins FCHo and SGIP Are Allosteric Activators of the AP2 Clathrin Adaptor Complex ELife. Oct, 2014 | Pubmed ID: 25303366 Corolla is a Novel Protein That Contributes to the Architecture of the Synaptonemal Complex of Drosophila Genetics. Sep, 2014 | Pubmed ID: 24913682 The SUN Protein Mps3 Controls Ndc1 Distribution and Function on the Nuclear Membrane The Journal of Cell Biology. Feb, 2014 | Pubmed ID: 24515347 Cohesion Promotes Nucleolar Structure and Function Molecular Biology of the Cell. Feb, 2014 | Pubmed ID: 24307683 Independence of Symmetry Breaking on Bem1-mediated Autocatalytic Activation of Cdc42 The Journal of Cell Biology. Sep, 2013 | Pubmed ID: 24062340 Binding of Drosophila Polo Kinase to Its Regulator Matrimony is Noncanonical and Involves Two Separate Functional Domains Proceedings of the National Academy of Sciences of the United States of America. Mar, 2013 | Pubmed ID: 23479640 Sequential Actin-based Pushing Forces Drive Meiosis I Chromosome Migration and Symmetry Breaking in Oocytes The Journal of Cell Biology. Mar, 2013 | Pubmed ID: 23439682 Quality Control: Putting Protein Aggregates in a Bind Current Biology : CB. Jan, 2013 | Pubmed ID: 23347944 Non-uniform Membrane Diffusion Enables Steady-state Cell Polarization Via Vesicular Trafficking Nature Communications. Jan, 2013 | Pubmed ID: 23340420 Cell-cycle-coupled Structural Oscillation of Centromeric Nucleosomes in Yeast Cell. Jul, 2012 | Pubmed ID: 22817893 Cohesin Proteins Promote Ribosomal RNA Production and Protein Translation in Yeast and Human Cells PLoS Genetics. 2012 | Pubmed ID: 22719263 Actin Depolymerization Drives Actomyosin Ring Contraction During Budding Yeast Cytokinesis Developmental Cell. Jun, 2012 | Pubmed ID: 22698284 Acetylation of the SUN Protein Mps3 by Eco1 Regulates Its Function in Nuclear Organization Molecular Biology of the Cell. Jul, 2012 | Pubmed ID: 22593213 The Arp2/3 Complex is Required for Lamellipodia Extension and Directional Fibroblast Cell Migration The Journal of Cell Biology. Apr, 2012 | Pubmed ID: 22492726 Flippase-mediated Phospholipid Asymmetry Promotes Fast Cdc42 Recycling in Dynamic Maintenance of Cell polarity Nature Cell Biology. Feb, 2012 | Pubmed ID: 22344035 Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory Cell. Feb, 2012 | Pubmed ID: 22284910 The SUN Protein Mps3 is Required for Spindle Pole Body Insertion into the Nuclear Membrane and Nuclear Envelope Homeostasis PLoS Genetics. Nov, 2011 | Pubmed ID: 22125491 Motility and Segregation of Hsp104-associated Protein Aggregates in Budding Yeast Cell. Nov, 2011 | Pubmed ID: 22118470 Dynamic Maintenance of Asymmetric Meiotic Spindle Position Through Arp2/3-complex-driven Cytoplasmic Streaming in Mouse Oocytes Nature Cell Biology. Aug, 2011 | Pubmed ID: 21874009 Fluorescence Fluctuation Spectroscopy and Imaging Methods for Examination of Dynamic Protein Interactions in Yeast Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21863494 Gamma-tubulin is Required for Bipolar Spindle Assembly and for Proper Kinetochore Microtubule Attachments During Prometaphase I in Drosophila Oocytes PLoS Genetics. Aug, 2011 | Pubmed ID: 21852952 BAC Modification Through Serial or Simultaneous Use of CRE/Lox Technology Journal of Biomedicine & Biotechnology. 2011 | Pubmed ID: 21197414 Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining Fengli Guo1, Melainia McClain1, Xia Zhao1, Kexi Yi1, Tari Parmely1, Jay Unruh1, Brian Slaughter1, Leonid Kruglyak2,3, Longhua Guo2,3, Alejandro Sánchez Alvarado1,2 1Stowers Institute for Medical Research, 2Howard Hughes Medical Institute, 3Department of Human Genetics, University of California Los Angeles JoVE 62713 Biologia
Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining Fengli Guo1, Melainia McClain1, Xia Zhao1, Kexi Yi1, Tari Parmely1, Jay Unruh1, Brian Slaughter1, Leonid Kruglyak2,3, Longhua Guo2,3, Alejandro Sánchez Alvarado1,2 1Stowers Institute for Medical Research, 2Howard Hughes Medical Institute, 3Department of Human Genetics, University of California Los Angeles JoVE 62713 Biologia