Jun Nagai Division of Functional Genomics and Therapeutic Innovation, Research Center for Advanced Genomics, Graduate School of Biomedical Sciences Nagasaki University Biography Publications Institution JoVE Articles Jun Nagai has not added a biography. If you are Jun Nagai and would like to personalize this page please email our Author Liaison for assistance. Publications Secreted PLA-III is a Possible Therapeutic Target to Treat Neuropathic Pain Biochemical and Biophysical Research Communications. 09, 2021 | Pubmed ID: 34237486 Establishment of Novel Protein Interaction Assays Between Sin3 and REST Using Surface Plasmon Resonance and Time-Resolved Fluorescence Energy Transfer International Journal of Molecular Sciences. Feb, 2021 | Pubmed ID: 33652591 Establishment of Novel High-Standard Chemiluminescent Assay for NTPase in Two Protozoans and Its High-Throughput Screening Marine Drugs. Mar, 2020 | Pubmed ID: 32183121 Novel Reporter System Monitoring IL-18 Specific Signaling Can Be Applied to High-Throughput Screening Marine Drugs. Jan, 2020 | Pubmed ID: 31963531 Abrogation of Lysophosphatidic Acid Receptor 1 Ameliorates Murine Vasculitis Arthritis Research & Therapy. 08, 2019 | Pubmed ID: 31429784 Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins Current Pharmaceutical Biotechnology. 2019 | Pubmed ID: 30727885 Involvement of Lysophosphatidic Acid-induced Astrocyte Activation Underlying the Maintenance of Partial Sciatic Nerve Injury-induced Neuropathic Pain Pain. Nov, 2018 | Pubmed ID: 29939962 Establishment of Novel Reporter Cells Stably Maintaining Transcription Factor-driven Human Secreted Alkaline Phosphatase Expression Current Pharmaceutical Biotechnology. 2018 | Pubmed ID: 29667554 High-Throughput Screening and Prediction Model Building for Novel Hemozoin Inhibitors Using Physicochemical Properties Antimicrobial Agents and Chemotherapy. 02, 2017 | Pubmed ID: 27919903 Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and Partners Arg124 During Receptor Activation Scientific Reports. Aug, 2015 | Pubmed ID: 26268898 Lysophosphatidic Acid and Its Receptors LPA1 and LPA3 Mediate Paclitaxel-induced Neuropathic Pain in Mice Molecular Pain. Nov, 2014 | Pubmed ID: 25411045 Interleukin-1β Plays Key Roles in LPA-induced Amplification of LPA Production in Neuropathic Pain Model Cellular and Molecular Neurobiology. Nov, 2013 | Pubmed ID: 23949386 An LPA Species (18:1 LPA) Plays Key Roles in the Self-amplification of Spinal LPA Production in the Peripheral Neuropathic Pain Model Molecular Pain. Jun, 2013 | Pubmed ID: 23773289 Lysophosphatidic Acid: Chemical Signature of Neuropathic Pain Biochimica Et Biophysica Acta. Jan, 2013 | Pubmed ID: 22960381 Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain over Long Periods in Both Diabetic and Spinal Cord Injury-induced Neuropathic Pain Models Journal of Pharmacological Sciences. 2012 | Pubmed ID: 22785019 Permanent Relief from Intermittent Cold Stress-induced Fibromyalgia-like Abnormal Pain by Repeated Intrathecal Administration of Antidepressants Molecular Pain. Sep, 2011 | Pubmed ID: 21933442 Antinociceptive Effect of Cyclic Phosphatidic Acid and Its Derivative on Animal Models of Acute and Chronic Pain Molecular Pain. May, 2011 | Pubmed ID: 21569544 Pre-emptive Morphine Treatment Abolishes Nerve Injury-induced Lysophospholipid Synthesis in Mass Spectrometrical Analysis Journal of Neurochemistry. Jul, 2011 | Pubmed ID: 21542849 Autotaxin and Lysophosphatidic Acid1 Receptor-mediated Demyelination of Dorsal Root Fibers by Sciatic Nerve Injury and Intrathecal Lysophosphatidylcholine Molecular Pain. Nov, 2010 | Pubmed ID: 21062487 Microglial Activation Mediates De Novo Lysophosphatidic Acid Production in a Model of Neuropathic Pain Journal of Neurochemistry. Nov, 2010 | Pubmed ID: 20722972 Calpain-mediated Down-regulation of Myelin-associated Glycoprotein in Lysophosphatidic Acid-induced Neuropathic Pain Journal of Neurochemistry. May, 2010 | Pubmed ID: 20420580 Absence of Morphine Analgesia and Its Underlying Descending Serotonergic Activation in an Experimental Mouse Model of Fibromyalgia Neuroscience Letters. Mar, 2010 | Pubmed ID: 20138970 Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord Through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain The Journal of Pharmacology and Experimental Therapeutics. May, 2010 | Pubmed ID: 20123931 Lysophosphatidic Acid-3 Receptor-mediated Feed-forward Production of Lysophosphatidic Acid: an Initiator of Nerve Injury-induced Neuropathic Pain Molecular Pain. Nov, 2009 | Pubmed ID: 19912636 Circadian-dependent Learning and Memory Enhancement in Nociceptin Receptor-deficient Mice with a Novel KUROBOX Apparatus Using Stress-free Positive Cue Task The Journal of Pharmacology and Experimental Therapeutics. Apr, 2007 | Pubmed ID: 17209168 Nucleoside Triphosphate Hydrolases Assay in Toxoplasm gondii and Neospora caninum for High-Throughput Screening using a Robot Arm Riho Kurata*1, Masamitsu Harada*2, Jun Nagai*3, Xiaofeng Cui*4, Takayuki Isagawa5, Hiroaki Semba6, Yasuhiro Yoshida7, Norihiko Takeda8, Koji Maemura9, Tomo Yonezawa3 1Education and Research Center for Pharmaceutical Sciences, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 2Independent Scholar, Tokyo, Japan, 3Division of Functional Genomics and Therapeutic Innovation, Research Center for Advanced Genomics, Graduate School of Biomedical Sciences, Nagasaki University, 4School of Chemistry, Chemical Engineering and Life Sciences, School of Materials and Engineering, Wuhan University of Technology, 5Data Science Center, Jichi Medical University, 6Department of Cardiovascular Medicine, The Cardiovascular Institute, 7Department of Immunology and Parasitology, University of Occupational and Environmental Health, 8Division of Cardiology and Metabolism, Center for Molecular Medicine, Jichi Medical University, 9Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University Hospital JoVE 62874 Biochimica
Nucleoside Triphosphate Hydrolases Assay in Toxoplasm gondii and Neospora caninum for High-Throughput Screening using a Robot Arm Riho Kurata*1, Masamitsu Harada*2, Jun Nagai*3, Xiaofeng Cui*4, Takayuki Isagawa5, Hiroaki Semba6, Yasuhiro Yoshida7, Norihiko Takeda8, Koji Maemura9, Tomo Yonezawa3 1Education and Research Center for Pharmaceutical Sciences, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 2Independent Scholar, Tokyo, Japan, 3Division of Functional Genomics and Therapeutic Innovation, Research Center for Advanced Genomics, Graduate School of Biomedical Sciences, Nagasaki University, 4School of Chemistry, Chemical Engineering and Life Sciences, School of Materials and Engineering, Wuhan University of Technology, 5Data Science Center, Jichi Medical University, 6Department of Cardiovascular Medicine, The Cardiovascular Institute, 7Department of Immunology and Parasitology, University of Occupational and Environmental Health, 8Division of Cardiology and Metabolism, Center for Molecular Medicine, Jichi Medical University, 9Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University Hospital JoVE 62874 Biochimica