Kazunori Nakajima Department of Anatomy Keio University School of Medicine Biography Publications Institution JoVE Articles Kazunori Nakajima has not added a biography. If you are Kazunori Nakajima and would like to personalize this page please email our Author Liaison for assistance. Publications Interactions Between Neural Cells and Blood Vessels in Central Nervous System Development BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Mar, 2024 | Pubmed ID: 38135890 Migratory Mode Transition of Astrocyte Progenitors in the Cerebral Cortex: an Intrinsic or Extrinsic Cell Process? Neural Regeneration Research. Mar, 2024 | Pubmed ID: 37721258 Heterozygous Null Mutation Disrupts Neocortical and Hippocampal Development ENeuro. Apr, 2023 | Pubmed ID: 36941061 A Unique "Reversed" Migration of Neurons in the Developing Claustrum The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2023 | Pubmed ID: 36631266 Activation of Sonic Hedgehog Signaling Promotes Differentiation of Cortical Layer 4 Neurons Via Regulation of Their Cell Positioning Journal of Developmental Biology. Nov, 2022 | Pubmed ID: 36547472 Erratic and Blood Vessel-guided Migration of Astrocyte Progenitors in the Cerebral Cortex Nature Communications. Nov, 2022 | Pubmed ID: 36323680 Development of Intensiometric Indicators for Visualizing N-cadherin Interaction Across Cells Communications Biology. Oct, 2022 | Pubmed ID: 36207396 Dab1-deficient Deep Layer Neurons Prevent Dab1-deficient Superficial Layer Neurons from Entering the Cortical Plate Neuroscience Research. Jul, 2022 | Pubmed ID: 35364133 Rhythmic Activation of Excitatory Neurons in the Mouse Frontal Cortex Improves the Prefrontal Cortex-mediated Cognitive Function Cerebral Cortex (New York, N.Y. : 1991). Nov, 2022 | Pubmed ID: 35136976 Comprehensive Characterization of Migration Profiles of Murine Cerebral Cortical Neurons During Development Using FlashTag Labeling IScience. Apr, 2021 | Pubmed ID: 33851097 Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2020 | Pubmed ID: 33009002 The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2020 | Pubmed ID: 32913108 Two-Photon Voltage Imaging of Spontaneous Activity from Multiple Neurons Reveals Network Activity in Brain Tissue IScience. Aug, 2020 | Pubmed ID: 32717641 VLDLR is Not Essential for Reelin-induced Neuronal Aggregation but Suppresses Neuronal Invasion into the Marginal Zone Development (Cambridge, England). Jun, 2020 | Pubmed ID: 32540847 Neuron-derived VEGF Contributes to Cortical and Hippocampal Development Independently of VEGFR1/2-mediated Neurotrophism Developmental Biology. Mar, 2020 | Pubmed ID: 31790655 Role of the Immune System in the Development of the Central Nervous System Frontiers in Neuroscience. 2019 | Pubmed ID: 31551681 Timing and Shaping Mechanisms of Neural Development Neuroscience Research. 01, 2019 | Pubmed ID: 30665588 Both Excitatory and Inhibitory Neurons Transiently Form Clusters at the Outermost Region of the Developing Mammalian Cerebral Neocortex The Journal of Comparative Neurology. Jul, 2019 | Pubmed ID: 30636008 Drebrin-like (Dbnl) Controls Neuronal Migration Via Regulating N-Cadherin Expression in the Developing Cerebral Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2019 | Pubmed ID: 30504273 Subtype Specification of Cerebral Cortical Neurons in Their Immature Stages Neurochemical Research. Jan, 2018 | Pubmed ID: 29185180 ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex Cerebral Cortex (New York, N.Y. : 1991). Jan, 2018 | Pubmed ID: 27909010 CHARGE Syndrome Modeling Using Patient-iPSCs Reveals Defective Migration of Neural Crest Cells Harboring CHD7 Mutations ELife. Nov, 2017 | Pubmed ID: 29179815 Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma EBioMedicine. Oct, 2017 | Pubmed ID: 28928015 Enhanced Expression of Pafah1b1 Causes Over-migration of Cerebral Cortical Neurons into the Marginal Zone Brain Structure & Function. Dec, 2017 | Pubmed ID: 28836069 Impaired Dendritic Growth and Positioning of Cortical Pyramidal Neurons by Activation of Aryl Hydrocarbon Receptor Signaling in the Developing Mouse PloS One. 2017 | Pubmed ID: 28820910 Association of Impaired Neuronal Migration with Cognitive Deficits in Extremely Preterm Infants JCI Insight. May, 2017 | Pubmed ID: 28515367 A Crossroad of Neuronal Diversity to Build Circuitry Science (New York, N.Y.). Apr, 2017 | Pubmed ID: 28450597 Reelin Transiently Promotes N-cadherin-dependent Neuronal Adhesion During Mouse Cortical Development Proceedings of the National Academy of Sciences of the United States of America. 02, 2017 | Pubmed ID: 28174271 Reelin and Neuropsychiatric Disorders Frontiers in Cellular Neuroscience. 2016 | Pubmed ID: 27803648 ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex Through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin ENeuro. 2016 | Pubmed ID: 27622210 DISC1 a Key Molecular Lead in Psychiatry and Neurodevelopment: No-More Disrupted-in-Schizophrenia 1 Molecular Psychiatry. Nov, 2016 | Pubmed ID: 27595595 SUMOylation of DISC1: a Potential Role in Neural Progenitor Proliferation in the Developing Cortex Molecular Neuropsychiatry. May, 2016 | Pubmed ID: 27525255 [Role of Reelin During Layer Formation in the Cerebral Neocortex] Brain and Nerve = Shinkei Kenkyu No Shinpo. Aug, 2016 | Pubmed ID: 27503821 The Mitotic Tensegrity Guardian Tau Protects Mammary Epithelia from Katanin-like1-induced Aneuploidy Oncotarget. Aug, 2016 | Pubmed ID: 27447563 Editorial: Mechanisms of Neuronal Migration During Corticogenesis Frontiers in Neuroscience. 2016 | Pubmed ID: 27199636 PDK1-Akt Pathway Regulates Radial Neuronal Migration and Microtubules in the Developing Mouse Neocortex Proceedings of the National Academy of Sciences of the United States of America. May, 2016 | Pubmed ID: 27170189 Mutually Repressive Interaction Between Brn1/2 and Rorb Contributes to the Establishment of Neocortical Layer 2/3 and Layer 4 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2016 | Pubmed ID: 26951672 Identity of Neocortical Layer 4 Neurons is Specified Through Correct Positioning into the Cortex ELife. Feb, 2016 | Pubmed ID: 26880563 In Utero Bisphenol A Exposure Induces Abnormal Neuronal Migration in the Cerebral Cortex of Mice Frontiers in Endocrinology. 2016 | Pubmed ID: 26869994 Proper Level of Cytosolic Disabled-1, Which Is Regulated by Dual Nuclear Translocation Pathways, Is Important for Cortical Neuronal Migration Cerebral Cortex (New York, N.Y. : 1991). Jul, 2016 | Pubmed ID: 26209842 Developmental Origin of Abnormal Dendritic Growth in the Mouse Brain Induced by in Utero Disruption of Aryl Hydrocarbon Receptor Signaling Neurotoxicology and Teratology. 2015 | Pubmed ID: 26526904 Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015 | Pubmed ID: 26354912 The COUP-TFII/Neuropilin-2 is a Molecular Switch Steering Diencephalon-derived GABAergic Neurons in the Developing Mouse Brain Proceedings of the National Academy of Sciences of the United States of America. Sep, 2015 | Pubmed ID: 26305926 Analysis of Cardiomyocyte Movement in the Developing Murine Heart Biochemical and Biophysical Research Communications. Sep, 2015 | Pubmed ID: 26168730 Cellular Dynamics of Neuronal Migration in the Hippocampus Frontiers in Neuroscience. 2015 | Pubmed ID: 25964735 Importance of Reelin C-terminal Region in the Development and Maintenance of the Postnatal Cerebral Cortex and Its Regulation by Specific Proteolysis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2015 | Pubmed ID: 25788693 Reelin Has a Preventive Effect on Phencyclidine-induced Cognitive and Sensory-motor Gating Deficits Neuroscience Research. Jul, 2015 | Pubmed ID: 25573715 Characterization of the Dipeptide Repeat Protein in the Molecular Pathogenesis of C9FTD/ALS Human Molecular Genetics. Mar, 2015 | Pubmed ID: 25398948 Reelin Receptors ApoER2 and VLDLR Are Expressed in Distinct Spatiotemporal Patterns in Developing Mouse Cerebral Cortex The Journal of Comparative Neurology. Feb, 2015 | Pubmed ID: 25308109 Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons Cerebral Cortex (New York, N.Y. : 1991). Apr, 2015 | Pubmed ID: 24142862 Cdk5 and Its Substrates, Dcx and P27kip1, Regulate Cytoplasmic Dilation Formation and Nuclear Elongation in Migrating Neurons Development (Cambridge, England). Sep, 2014 | Pubmed ID: 25183872 How Does Reelin Control Neuronal Migration and Layer Formation in the Developing Mammalian Neocortex? Neuroscience Research. Sep, 2014 | Pubmed ID: 24969097 Time-lapse Imaging of Cell Cycle Dynamics During Development in Living Cardiomyocyte Journal of Molecular and Cellular Cardiology. Jul, 2014 | Pubmed ID: 24704900 Hippocampal Pyramidal Neurons Switch from a Multipolar Migration Mode to a Novel "climbing" Migration Mode During Development The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2014 | Pubmed ID: 24453304 [Neuronal Distribution in the Cerebral Cortex and Its Significance in Schizophrenia] Brain and Nerve = Shinkei Kenkyu No Shinpo. Oct, 2013 | Pubmed ID: 24101425 DISC1: a Key Lead in Studying Cortical Development and Associated Brain Disorders The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Oct, 2013 | Pubmed ID: 23300216 Reelin Controls Neuronal Positioning by Promoting Cell-matrix Adhesion Via Inside-out Activation of Integrin α5β1 Neuron. Oct, 2012 | Pubmed ID: 23083738 A Phosphatidylinositol Lipids System, Lamellipodin, and Ena/VASP Regulate Dynamic Morphology of Multipolar Migrating Cells in the Developing Cerebral Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2012 | Pubmed ID: 22915108 Migratory Pathways of GABAergic Interneurons when They Enter the Neocortex The European Journal of Neuroscience. Jun, 2012 | Pubmed ID: 22639844 Leucine-rich Glioma Inactivated 1 (Lgi1), an Epilepsy-related Secreted Protein, Has a Nuclear Localization Signal and Localizes to Both the Cytoplasm and the Nucleus of the Caudal Ganglionic Eminence Neurons The European Journal of Neuroscience. Aug, 2012 | Pubmed ID: 22612501 GABAergic Interneuron Migration and the Evolution of the Neocortex Development, Growth & Differentiation. Apr, 2012 | Pubmed ID: 22524606 Segregation and Pathfinding of Callosal Axons Through EphA3 Signaling The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2011 | Pubmed ID: 22072676 N-cadherin Regulates Radial Glial Fiber-dependent Migration of Cortical Locomoting Neurons Communicative & Integrative Biology. May, 2011 | Pubmed ID: 21980571 GABAergic Precursor Transplantation into the Prefrontal Cortex Prevents Phencyclidine-induced Cognitive Deficits The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2011 | Pubmed ID: 21976496 [What Does Reelin Control to Regulate Neuronal Layer Formation in the Developing Cerebral Cortex?] Seikagaku. The Journal of Japanese Biochemical Society. Aug, 2011 | Pubmed ID: 21942094 The Outermost Region of the Developing Cortical Plate is Crucial for Both the Switch of the Radial Migration Mode and the Dab1-dependent "inside-out" Lamination in the Neocortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21697392 PDK1-Foxo1 in Agouti-related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure PloS One. 2011 | Pubmed ID: 21694754 Disrupted-in-Schizophrenia-1 (Disc1) is Necessary for Migration of the Pyramidal Neurons During Mouse Hippocampal Development Human Molecular Genetics. Jul, 2011 | Pubmed ID: 21540240 Changes in Cortical Interneuron Migration Contribute to the Evolution of the Neocortex Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21518872 DISC1-dependent Switch from Progenitor Proliferation to Migration in the Developing Cortex Nature. May, 2011 | Pubmed ID: 21471969 Regulation of Cortical Neuron Migration by the Reelin Signaling Pathway Neurochemical Research. Jul, 2011 | Pubmed ID: 21253854 Cellular Composition and Organization of the Subventricular Zone and Rostral Migratory Stream in the Adult and Neonatal Common Marmoset Brain The Journal of Comparative Neurology. Mar, 2011 | Pubmed ID: 21246550 Neural Crest-derived Stem Cells Migrate and Differentiate into Cardiomyocytes After Myocardial Infarction Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2011 | Pubmed ID: 21212399 Migration Defects by DISC1 Knockdown in C57BL/6, 129X1/SvJ, and ICR Strains Via in Utero Gene Transfer and Virus-mediated RNAi Biochemical and Biophysical Research Communications. Oct, 2010 | Pubmed ID: 20807500 Rab GTPases-dependent Endocytic Pathways Regulate Neuronal Migration and Maturation Through N-cadherin Trafficking Neuron. Aug, 2010 | Pubmed ID: 20797536 Ectopic Reelin Induces Neuronal Aggregation with a Normal Birthdate-dependent "inside-out" Alignment in the Developing Neocortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2010 | Pubmed ID: 20720102 Knockdown of DISC1 by in Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits Neuron. Feb, 2010 | Pubmed ID: 20188653 Role of Dual Leucine Zipper-bearing Kinase (DLK/MUK/ZPK) in Axonal Growth Neuroscience Research. Jan, 2010 | Pubmed ID: 19808064 Downregulation of Functional Reelin Receptors in Projection Neurons Implies That Primary Reelin Action Occurs at Early/premigratory Stages The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2009 | Pubmed ID: 19710317 Selective Induction of Neocortical GABAergic Neurons by the PDK1-Akt Pathway Through Activation of Mash1 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19549840 Differences of Migratory Behavior Between Direct Progeny of Apical Progenitors and Basal Progenitors in the Developing Cerebral Cortex Cerebral Cortex (New York, N.Y. : 1991). Sep, 2009 | Pubmed ID: 19150920 COUP-TFII is Preferentially Expressed in the Caudal Ganglionic Eminence and is Involved in the Caudal Migratory Stream The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008 | Pubmed ID: 19074032 Recruitment of PCM1 to the Centrosome by the Cooperative Action of DISC1 and BBS4: a Candidate for Psychiatric Illnesses Archives of General Psychiatry. Sep, 2008 | Pubmed ID: 18762586 The Cortical Subventricular Zone-specific Molecule Svet1 is Part of the Nuclear RNA Coded by the Putative Netrin Receptor Gene Unc5d and is Expressed in Multipolar Migrating Cells Molecular and Cellular Neurosciences. Aug, 2008 | Pubmed ID: 18547816 Cell-autonomous Roles of ARX in Cell Proliferation and Neuronal Migration During Corticogenesis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2008 | Pubmed ID: 18509041 Labeling Embryonic Mouse Central Nervous System Cells by in Utero Electroporation Development, Growth & Differentiation. Aug, 2008 | Pubmed ID: 18482404 [Mechanisms of Cerebral Cortical Development] Brain and Nerve = Shinkei Kenkyu No Shinpo. Apr, 2008 | Pubmed ID: 18421981 Migratory Behavior of Presumptive Interneurons is Affected by AMPA Receptor Activation in Slice Cultures of Embryonic Mouse Neocortex Developmental Neuroscience. 2008 | Pubmed ID: 18075259 Identification of Molecules Preferentially Expressed Beneath the Marginal Zone in the Developing Cerebral Cortex Neuroscience Research. Feb, 2008 | Pubmed ID: 18055048 Computational Cell Model Based on Autonomous Cell Movement Regulated by Cell-cell Signalling Successfully Recapitulates the "inside and Outside" Pattern of Cell Sorting BMC Systems Biology. Sep, 2007 | Pubmed ID: 17883828 Control of Tangential/non-radial Migration of Neurons in the Developing Cerebral Cortex Neurochemistry International. 2007 | Pubmed ID: 17588709 Expression Profiles of Insulin-like Growth Factor Binding Protein-like 1 in the Developing Mouse Forebrain Gene Expression Patterns : GEP. Feb, 2007 | Pubmed ID: 17175204 Mouse Disabled1 (DAB1) is a Nucleocytoplasmic Shuttling Protein The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 17062576 Identification of Ventricular-side-enriched Molecules Regulated in a Stage-dependent Manner During Cerebral Cortical Development The European Journal of Neuroscience. Jan, 2006 | Pubmed ID: 16420439 Switching of Alpha-catenin from AlphaE-catenin in the Cortical Ventricular Zone to AlphaN-catenin II in the Intermediate Zone Brain Research. Developmental Brain Research. Nov, 2005 | Pubmed ID: 16185771 The Caudal Migratory Stream: a Novel Migratory Stream of Interneurons Derived from the Caudal Ganglionic Eminence in the Developing Mouse Forebrain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2005 | Pubmed ID: 16079409 Birth-date-dependent Segregation of the Mouse Cerebral Cortical Neurons in Reaggregation Cultures The European Journal of Neuroscience. Jul, 2005 | Pubmed ID: 16045486 Neuronal Migration in Cortical Development Journal of Child Neurology. Apr, 2005 | Pubmed ID: 15921226 Expression Profiles of EphA3 at Both the RNA and Protein Level in the Developing Mammalian Forebrain The Journal of Comparative Neurology. Jul, 2005 | Pubmed ID: 15892098 Birth-date Dependent Alignment of GABAergic Neurons Occurs in a Different Pattern from That of Non-GABAergic Neurons in the Developing Mouse Visual Cortex Neuroscience Research. Aug, 2004 | Pubmed ID: 15236865 Multipolar Migration: the Third Mode of Radial Neuronal Migration in the Developing Cerebral Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2003 | Pubmed ID: 14602813 Cellular and Molecular Mechanisms of Neuronal Migration in Neocortical Development Seminars in Cell & Developmental Biology. Jun, 2003 | Pubmed ID: 12948351 Cell and Molecular Mechanisms That Control Cortical Layer Formation in the Brain The Keio Journal of Medicine. Mar, 2003 | Pubmed ID: 12713017 Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain Hidenori Tabata1,2, Koh-ichi Nagata2, Kazunori Nakajima1 1Department of Anatomy, Keio University School of Medicine, 2Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center JoVE 66631 Neuroscienze
Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain Hidenori Tabata1,2, Koh-ichi Nagata2, Kazunori Nakajima1 1Department of Anatomy, Keio University School of Medicine, 2Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center JoVE 66631 Neuroscienze