Center for High Pressure Science and Technology Advanced Research 1 article published in JoVE Engineering Determining the Mechanical Strength of Ultra-Fine-Grained Metals Jianing Xu*1,2, Yanju Wang*2, Jinyuan Yan3, Bin Chen1,2 1School of Science, Harbin Institute of Technology, 2Center for High Pressure Science and Technology Advanced Research, 3Advanced Light Source, Lawrence Berkeley National Lab The protocol presented here describes the high-pressure radial diamond-anvil-cell experiments and analyzing the related data, which are essential for obtaining the mechanical strength of the nanomaterials with a significant breakthrough to the traditional approach.