Instituto de Investigacion Sanitaria Hospital de la Princesa 1 article published in JoVE Medicine Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients Ancor Sanz-García1, Lorena Vega-Zelaya2, Jesús Pastor2, Cristina V. Torres1, Rafael G. Sola1, Guillermo J. Ortega1,3 1Neurosurgery & National Reference Unit for the Treatment of Refractory Epilepsy, Instituto de Investigación Sanitaria Hospital de la Princesa, 2Clinical Neurophysiology & National Reference Unit for the Treatment of Refractory Epilepsy, Instituto de Investigación Sanitaria Hospital de la Princesa, 3CONICET This protocol describes a procedure to track the evolution of mesial network measures in temporal lobe epilepsy (TLE) patients. It is based on the combination of intracranial recordings with a novel numerical technique for data analysis. Specifically, we present a protocol for network analyses of foramen ovale recordings.