MatTek Corporation View Institution's Website 2 articles published in JoVE Bioengineering Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model Yulia Kaluzhny1, Helena Kandárová2, Laurence d’Argembeau-Thornton1, Paul Kearney1, Mitchell Klausner1 1MatTek Corporation, 2MatTek In Vitro Life Science Laboratories We have developed an eye irritation test which utilizes a three dimensional reconstructed human cornea-like epithelial (RhCE) tissue model. The test is able to discriminate between ocular irritant and corrosive materials (GHS Categories 1 and 2 combined) and those that do not require labeling (GHS No Category). Biology An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model Helena Kandárová1, Patrick Hayden1, Mitchell Klausner1, Joseph Kubilus1, John Sheasgreen1 1MatTek Corporation In this video, we demonstrate the EpiDerm Skin Irritation test (EpiDerm SIT) developed and validated for in vitro skin irritation testing of chemicals, including cosmetic and pharmaceutical ingredients.